Department of Surgical Sciences

Postal address
Akademiska sjukhuset entrence 70, 1 tr
SE-751 85 Uppsala

Visiting address
Akademiska sjukhuset entrence 70, 1 tr

Invoice address
Uppsala University
SE-737 84 Fagersta

Reference number 463

Fax: +46 18 55 93 57


Head of Department
Per Hellman
+46 18 611 46 17

Financial Administration
Siv Utterberg
+46 18 611 48 55

Siv Andersson
+46 18 611 26 16

Course Administration
Isabel Eriksson Vestin
+46 18 611 31 02

Annika Häger
+46 18 611 48 15

Åsa Eriksson
+46 18 611 53 65

Human Resource Administration
Karin Johansson
+46 18 611 31 03

Higran Saghir
+46 18 611 49 27

Organization Number

Registration number for value-added tax VAT SE202100293201


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Endocrine Surgery

The Endocrine Surgical Research Group runs studies of genetics, diagnosis and treatment of endocrine tumours, in order to identify genes involved in tumour development and progression, and to ultimately provide possibilities for new treatment. In clinical studies genetic changes are related to the disease course of individual tumours, with the overall aim to improve diagnosis and treatment in patients with endocrine tumour disease. 

Genetics and treatment of endocrine tumors 

Endocrine tumours are of special interest in tumour biology because of a common extended disease course, and often presence of only few specific genetic changes, which can be related to variable tumour biology. For many endocrine tumours histopathology can often not distinguish tumours with more malignant biological features, and there is a general hope that genetic differences will provide better means of discrimination. Genetic studies are expected to become of great importance for the clinical management by predicting prognosis, and genetic defects may be used as targets for new treatment. The overall aim of the studies is to identify tumour genes and other prognostic markers of importance for the development and progression of endocrine tumours, reveal gene changes with new technology, and investigate new possibilities of treatment against tumour progression. 


As an overall resource we have access to >3000 specimens and blood samples from patients operated for endocrine tumours during >20 years. The samples, stored at Uppsala Biobank, have being used in many previous studies and is a valuable and important source in our studies. 


Adrenomedullary tumors - Pheochromocytoma 

Studies of pheochromocytoma and paraganglioma have used the latest DNA sequencing techniques in order to characterize polymorphisms, mutations, deletions and insertions in DNA, from both benign and malignant tumours. Epigenetic derangements have been studied, and the research is performed in close collaboration with the group of Experimental Surgery.

Adrenocortical tumours 

In a study performed in collaborations with Yale University, and which was published in Science, the breakthrough of genetic knowledge of adrenal tumours was initiated. A mutation in KCNJ5, an ion channel, was noted in approximately 45% of tumours. Further, we have revealed mutations in CACNA1D in a subset of these tumours as well, and in the cortisol-producing tumours in PRKACA. We are currently looking at differencies between benign and malignant adrenal tumours, also on the epigenetic level.


Our parathyroid studies are currently focused on identifying differences between parathyroid adenoma and carcinoma. We have noted that derangements in the structure or function of beta cathenin, HIC1, APC, EZH2 may be important, as well as differences in methylation or hydromethylation in the parathyroid tissue.

Small intestinal Neuroendocrine tumours (SI-NET; formerly midgut carcinoids)

SI-NETs have been studied with several different methods in order to identify molecular derangements to understand the underlying mechanisms for tumour development. Initially, we identified the presence of a suspect tumour suppressor gene for SI-NETs on chromosome 18q. Further studies have utilized expression microarrays, sequencing and methylation arrays to reveal characteristics for more or less aggressive tumours. We have identified bad prognostic signs in presence of peritoneal carcinosis and are currently investigating the Clinical studies have established a cohort of >600 individuals with SI-NET, in which we have characterized novel prognostic factors, especially peritoneal carcinomatosis. This is further analyzed by performing SNP and expression arrays and CNV analyses for determining the genetic signature. A nested case-control study of 900 individuals has passed the data collecting phase and is now in the analysis phase.

Pancreatic NETs 

Several previous studies have investigated gene changes associated with pancreatic NETs. In a recent study we could after exome sequencing identify mutations in YY1 in approximately 40% of insulinomas. Further work includes characterization of DAXX mutations and expression. Further analyses of genetic derangements in multiple endocrine neoplasia type 1 (MEN1) is also performed. 

Clinical studies 

Clinical studies of primary hyperparathyroidism (HPT) focus on relations between calcium and/or parathyroid hormone (PTH) and aldosterone, and increased mortality in cardiovascular disease, utilizing epidemiological methods but also the PIVUS cohort, a well characterized cohort which has been followed for 10 years and thoroughly scrutinized regarding vascular changes, atherosclerosis and cardiovascular morbidity. The calcium metabolic situation in obese individuals as well as after gastric by-pass is also studied using Cica-clamp and intervention with vitamin D treatment among several methods.

Graves' disease

This disease is studied regarding the calcium metabolic regulation, highlighting skeletal derangements, unknown autoimmune antibodies and genetic predisposition by SNP arrays.

Members of the group 2016

Senior investigators
Gunnar Westin, Professor, Molecular genetics and epigenetics of endocrine tumours
Per Hellman, Professor, Endocrine surgery
Peter Stålberg, Ass Professor, Endocrine surgery
Olov Norlén, MD, PhD

Ola Hessman, MD, PhD - attending surgeon
Hella Hultin, MD, PhD - attending surgeon

Birgitta Bondeson

PhD students
John Eriksson (Prognosis of SI-NETs)
Elham Barazeghi (Parathyroid research)
Rajani Maharjan (Adrenal tumours)
Johan Kugelberg (Adrenal Tumours)
Kosmas Daskalakis (SI-NET)

Dissertations (last 5 years)
Maria Annerbo
Tobias Åkerström
Katarina Edfeldt
Joakim Crona
Alberto Delgado Verdugo
Hella Hultin
Jessica Svedlund
Olov Norlén
Johanna Sandgren
Niklas Zar
Joakim Hennings
Tijana Krajisnik

The last years publikations are depicted in the Institutions Research Report Annual report. Earlier and later articles can be searched in the database for publikations DiVA (Digitala Vetenskapliga Arkivet – Digital scientific archive).


Collaboration is continuously running with other groups within Academic Hospital: Uppsala Centre of Excellence for Endocrine Tumors.

Collaboration also continuous with Yale University (Endocrine Neoplasia Laboratory, Dept of Surgery, responsible Ass Professor T Carling – with previous dissertation within our research group, and Professor Richard Lifton) for studie of tumor genetics with new methods. P Björklund has established “Experim.ental Endocrine Surgery” which we collaborate with closely.

Collaboration also continuous with other international groups:
Professor H Dralle, Halle, Germany, Martin Walz, Essen, Germany, Ass Professor Kenko Cupisti, Dusseldorf, Tyskland

Annual report 2016

Each year, the department present their research in an Annual report of the research conducted.

In the report there are articles that the groups have publiched during the last three years. Newer and older articles are to be found in DiVA.

Verksamma inom endokrin-kirurgi

Länk till universitetskatalogen, här finns alla medarbetare som är verksamma inom endokrinkirurgi.