Upper abdominal surgery

The research in Upper abdominal surgery is focused on four main areas; esophageal and gastric cancer, bariatric surgery, hepatic surgery, and biliary- and pancreatic surgery.

Esophageal and Gastric Cancer

Principal investigator: Magnus Sundbom

In the field of esophageal- and gastric cancer, we study the use of PET-MRI for loco-regional evaluation of esophageal cancer and the use of micro dialysis to identify early ischemia in the gastric tube. We participate in an international multicenter study on early complications. Patient outcome is studied on a national level in collaboration with the national quality register, NREV.

Duodenal switch

Bariatric Surgery

Principal investigator: Magnus Sundbom

In bariatric surgery, we have three main areas of research; surgical technique, postoperative changes in gastrointestinal physiology and long term results. Our research is clinical and based on operated patients with the aim to improve surgical technique and understand the altered physiology. We perform Duodenal Switch (DS) in patients with super obesity, i.e. BMI>50 kg/m2, and laparoscopic gastric bypass (GBP) and gastric sleeve (GS) routinely.

At present, we are conducting a national study on treatment of early complications, changes in gastrointestinal function, calcium and vitamin-D, as well as long term results after duodenal switch and gastric bypass in patients with BMI>50. We are also performing a 10-year follow-up of all our GBP-operated patients, demonstrating good weight result in satisfied patients. The general effects of bariatric surgery on gastrointestinal function is studied in several PhD projects, using blood sampling and validated questionnaires.

Much of our work is performed in collaboration with other units in the hospital or at the University, such as the Dept of Endocrinology, the Metabolic unit at the University Hospital, and the Institution of Radiology, Oncology, and Radiation Sciences.

Members of the research group Esophageal/Gastric cancer and Bariatric surgery 2018

Magnus Sundbom, Professor
Jakob Hedberg, Ass professor
David Edholm, MD, PhD
Eduardo Sima, MD, PhD
Gustav Linder, MD, PhD
Zakaria Bekhali, MD
Martin Skogar, MD
Khalid Elias, MD
Bjarni Vidarsson, MD
Eladio Cabrera, MD
Katarina Stevens, MD

Hepatic Surgery

Principal investigator: Ulf Haglund

In hepatic surgery we have focused on defining the possible risk following liver resection induced by pre-operative chemotherapy. We have studied the clinical outcome in the patient material from our institution of approximately 500 resected patients with liver metastasis from colo-rectal cancer during the last 12 years. More than half of the patients receive pre-operative chemotherapy and some patients develop sinusoidal obstructions syndrome. In a project using pre-operative 3T MR we have studied patients with and with-out pre-operative chemotherapy the day before surgery with special techniques to reveal and grade steatosis, steatohepatitis and portal flow. The results are related to the histopathological evaluation and to the clinical outcome. Two of the studies are recently published and further MR studies are planned. In collaboration with prof. Per Artursson, department of pharmacy, we have studies aimed at developing a model using cultured human liver cells, obtained from waste liver tissue after resection for tumours. The cultured cells will be used to study membrane transport function, the influence of preoperative chemotherapy as well as the influence of cytostatic drugs on this function. A safety and effect study on irreversible electroporation (IRE) for liver tumours (as a complement to liver surgery, maximum 2 with a diameter of 3 cm) are running.

Members of the research group
Ulf Haglund, MD, PhD, Professor Emeritus
Agneta Norén, MD, PhD
Frans Duraj, MD
Jozef Urdzik, MD
 

Biliary-Pancreatic Surgery

Principal investigator: Britt-Marie Karlson

The biliary-pancreatic group has focused on surgery for gall stones, perioperative cholangiography.and quality of life. Long term results after endoscopic sphincterotomy, particularly in patients with gall stone-related pancreatitis, are under evaluation. A novel project on irreversible electroporation (IRE) in patients with inoperable pancreatic cancer has started. In collaboration with Department of Medical Sciences, studies in primary sclerosing cholangitis are ongoing and a consecutive patient material with this disease is accumulated with endoscopic cholangiographic data.

Members of the research group
Britt-Marie Karlson, MD, PhD
Stefan Linder, Associate Professor, MD, PhD
Ann Langerth, MD
Christopher Månsson, MD