Department of Surgical Sciences

Postal address
Akademiska sjukhuset entrence 70, 1 tr
SE-751 85 Uppsala

Visiting address
Akademiska sjukhuset entrence 70, 1 tr

Invoice address
Uppsala University
PG1254
SE-737 84 Fagersta

Reference number 463

Fax: +46 18 55 93 57

E-mail
surgsci@surgsci.uu.se

Head of Department
Per Hellman
+46 18 611 46 17

Financial Administration
Siv Utterberg
+46 18 611 48 55

Siv Andersson
+46 18 611 26 16

Course Administration
Isabel Eriksson Vestin
+46 18 611 31 02

Annika Häger
+46 18 611 48 15

Åsa Eriksson
+46 18 611 53 65

Human Resource Administration
Karin Johansson
+46 18 611 31 03

Higran Saghir
+46 18 611 49 27

Organization Number
202100-2932

Registration number for value-added tax VAT SE202100293201

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Upper abdominal surgery

The research in Upper abdominal surgery is focused on four main areas; esophageal and gastric cancer, bariatric surgery, hepatic surgery, and biliary- and pancreatic surgery.


Esophageal and Gastric Cancer

Principal investigator: Magnus Sundbom

In the field of esophageal- and gastric cancer, we participate in the international CRITICS-study on adjuvant chemo-radiation in gastric cancer and perform vitro evaluation of chemotherapy for gastric- and esophageal cancer as well as detailed loco-regional evaluation of esophageal cancer with 3T MRI and endoscopic ultrasound. In esophageal resections, the gastric tube is evaluated with continuous pHi-measurements in an attempt to identify early ischemia. Patient outcome is studied on a national level in collaboration with the national quality register, NREV.

Duodenal switch

Bariatric Surgery

Principal investigator: Magnus Sundbom

In bariatric surgery, we have three main areas of research; surgical technique, postoperative changes in gastrointestinal physiology and long term results. Our research is clinical and based on operated patients with the aim to improve surgical technique and understand the altered physiology. We perform Duodenal Switch (DS) in patients with super obesity, i.e. BMI>50 kg/m2, and laparoscopic gastric bypass (GBP) routinely.

At present, we are conducting studies in preoperative reduction of liver fat, different anastomotic techniques, appetite-regulation in operated patients and controls as well as calcium homeostasis and vitamin-D levels. In collaboration with Örebro, we have finished a 10-year follow-up of 880 GBP-operated patients, demonstrating good weight result in generally satisfied patients. We are at present evaluating body composition and bone mineral density after different types of bariatric surgery. The general effects of bariatric surgery on gastrointestinal function is studied in several PhD projects, using blood sampling and validated questionnaires.

Much of our work is performed in collaboration with other units in the hospital or at the University, such as the Dept of Endocrinology, the Metabolic unit at the University Hospital, and MRI, Institution of Radiology, Oncology, and Radiation Sciences.

Members of the research group Esophageal/Gastric cancer and Bariatric surgery
Magnus Sundbom, Professor
Jakob Hedberg, Ass professor
David Edholm, MD, PhD
Eduardo Sima, MD, PhD
Zakaria Bekhali, MD
Gustav Linder, MD
Martin Skogar, MD
Khalid Elias, MD
Bjarni Vidarsson, MD
Eladio Cabrera, MD
Katarina Stevens, MD
 

Hepatic Surgery

Principal investigator: Ulf Haglund

In hepatic surgery we have focused on defining the possible risk following liver resection induced by pre-operative chemotherapy. We have studied the clinical outcome in the patient material from our institution of approximately 500 resected patients with liver metastasis from colo-rectal cancer during the last 12 years. More than half of the patients receive pre-operative chemotherapy and some patients develop sinusoidal obstructions syndrome. In a project using pre-operative 3T MR we have studied patients with and with-out pre-operative chemotherapy the day before surgery with special techniques to reveal and grade steatosis, steatohepatitis and portal flow. The results are related to the histopathological evaluation and to the clinical outcome. Two of the studies are recently published and further MR studies are planned. In collaboration with prof. Per Artursson, department of pharmacy, we have studies aimed at developing a model using cultured human liver cells, obtained from waste liver tissue after resection for tumours. The cultured cells will be used to study membrane transport function, the influence of preoperative chemotherapy as well as the influence of cytostatic drugs on this function. A safety and effect study on irreversible electroporation (IRE) for liver tumours (as a complement to liver surgery, maximum 2 with a diameter of 3 cm) are running.

Members of the research group
Ulf Haglund, MD, PhD, Professor Emeritus
Agneta Norén, MD, PhD
Frans Duraj, MD
Jozef Urdzik, MD
 

Biliary-Pancreatic Surgery

Principal investigator: Britt-Marie Karlson

The biliary-pancreatic group has focused on surgery for gall stones, perioperative cholangiography.and quality of life. Long term results after endoscopic sphincterotomy, particularly in patients with gall stone-related pancreatitis, are under evaluation. A novel project on irreversible electroporation (IRE) in patients with inoperable pancreatic cancer has started. In collaboration with Department of Medical Sciences, studies in primary sclerosing cholangitis are ongoing and a consecutive patient material with this disease is accumulated with endoscopic cholangiographic data.

Members of the research group
Britt-Marie Karlson, MD, PhD
Stefan Linder, Associate Professor, MD, PhD
Ann Langerth, MD
Christopher Månsson, MD
 

Annual report 2016

Each year, the department present their research in an Annual report of the research conducted.

In the report there are articles that the groups have publiched during the last three years. Newer and older articles are to be found in DiVA.

Verksamma inom gastro-intestinalkirurgi

Länk till universitetskatalogen, här finns alla medarbetare som är verksamma inom gastrointestinalkirurgi.