Department of Surgical Sciences

Postal address
Akademiska sjukhuset entrence 70, 1 tr
SE-751 85 Uppsala

Visiting address
Akademiska sjukhuset entrence 70, 1 tr

Invoice address
Uppsala University
PG1254
SE-737 84 Fagersta

Reference number 463

Fax: +46 18 55 93 57

E-mail
surgsci@surgsci.uu.se

Head of Department
Per Hellman
+46 18 611 46 17

Financial Administration
Siv Utterberg
+46 18 611 48 55

Siv Andersson
+46 18 611 26 16

Course Administration
Isabel Eriksson Vestin
+46 18 611 31 02

Annika Häger
+46 18 611 48 15

Åsa Eriksson
+46 18 611 53 65

Human Resource Administration
Karin Johansson
+46 18 611 31 03

Higran Saghir
+46 18 611 49 27

Organization Number
202100-2932

Registration number for value-added tax VAT SE202100293201

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Experimental Surgery

The group of Experimental Surgery has started as an independent research group in January 2012, supported by a Young Investigator Award and project grants from Swedish Cancer Society.

We utilize state of the art methods such as Next Generation Sequencing (NGS), high throughput array technologies, In Situ sequencing and drug screening of viable primary tumour cells.

Personalized Medicine, Precision Medicine

In partnership with SciLifeLab, clinical diagnostics platform and utilizing high density SNP array technology and Next Generation Sequencing, we aim to develop a fast and affordable diagnostic tool to identify genetic and epigenetic aberration in each individual tumour. Viable tumour cells are then subjected to screening for druggable targets.

Adrenal tumours; genetics, epigenetics and new therapeutic strategies

In pheochromocytoma tumours we have identified mutations in HRAS. This finding introduces possibilities for targeted therapy in non-resectable tumours. In parallel we have developed an NGS based mutation screening method to identify patients with hereditary pheochromocytoma and paragangliomas.

Screening of viable primary tumour cells for candidate drugs have shown induction of apoptosis by somatostatin analogues and other agents affecting the methylation activity.

In cortisol producing tumours we have identified recurrent mutations in PRKACA and are performing drug screening tests on primary tumour cell cultures.

Complicated Graves Disease

Even though Graves thyrotoxicosis is a common disease, complications such as disrupted calcium homeostasis and ophthalmopathy are rare. We aim to identify genetic determinants predisposing for complications.

Rare Mendelian inherited conditions

In collaboration with several international and national groups we are utilizing NGS to identify genes responsible for rare syndromes.

Endocrine disrupting chemicals and adrenal disorders

As a part of an international consortium led by associate professor Monica Lind UU and professor Bruce Blumberg University of California, Irvine, we aim to determine physiological effects of Bisfenol A on adrenals and kidneys.

Clinical studies

In collaboration with other groups, we are evaluating a new target for positron-emission-tomography (PET) for diagnosis of adrenal tumours, aiming at improved diagnostic imaging procedure.

Computational Medicine

We have developed the first mobile application for assistance in decision making in the clinical genetic testing for pheochromocytoma and paraganglioma susceptibility genes (PHEGEN), available for free download.
 

Members of the group during 2016

Peyman Björklund, Principal Investigator
Per Hellman, Professor, Principal Investigator
Rajani Maharjan, MS, PhD student
Tobias Åkerström, MD, PhD student
Maria Annerbo, MD, PhD student
Samuel Backman, MD student
Joakim Crona, MD, PhD
Lee Starker, MD, PhD
Alberto Falk Delgado, MD, PhD