Medicinsk epidemiologi
Forskargruppen medicinsk epidemiologi finns i Epihubben, en arbetsplats och nätverk för epidemiologisk forksning inom Vetenskapsområdet medicin och farmaci, med lokaler i MTC-huset, Dag Hammarskjölds väg 14B (karta). Här samlas forskare från olika institutioner som ägnar sig åt epidemiologisk forskning. Ambitionen är att över forskargruppsgränserna utbyta erfarenheter och inspirera till nya forskningsprojekt och tillsammans bygga en långsiktig grund för avancerad epidemiologisk forskning.

Vårt huvudsakliga forskningsområde omfattar sjukdomar och tillstånd i den åldrande befolkningen, inklusive fragilitetsfrakturer, hjärt-kärlsjukdom och cancer, men vi är även involverade i andra epidemiologiska forskningsområden. Vi kombinerar traditionella epidemiologiska metoder med moderna metoder från området kausal inferens och applicerar dessa på observationsstuder. Vi utför även randomiserade interventionsstudier. Läs mer om vår forskning genom att titta igenom vår publikationslista.
SIMPLER
Karl Michaëlsson, forskargruppsledare för Medicinsk epidemiologi, är också föreståndare för den nationella infrastrukturen SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se). Mycket av vår forskning baseras på kohorterna som ingår i SIMPLER. Sedan slutet av 2018 leds SIMPLER av ett konsortium bestående av Uppsala universitet, Karolinska institutet, Chalmers tekniska högskola och Örebro universitet, i samarbete med Region Uppsala, Västmanland och Örebro.
Infrastrukturen har till uppgift att förse nationella och internationella forskare med material för forskning om hur kost- och livsstilsfaktorer men också genetik påverkar vår hälsa under framför allt den senare delen av livet. Kunskapen kan användas för att till exempel utveckla råd och rekommendationer om kost och livsstil, utveckla nya markörer för att enklare och effektivare diagnostisera kroniska sjukdomar och dess förstadier och utveckla nya individanpassade behandlingsmetoder.
Finansiering
Forskargruppen har fått finansiering från Vetenskapsrådet, Forte, Hjärt-lungfonden, Cancerfonden, Hjärnfonden och ALF.
Medlemmar i forskargruppen
Gruppen leds av Karl Michaëlsson, professor i medicinsk epidemiologi och överläkare i ortopedisk kirurgi.
Gruppmedlemmar (kontaktinformation)
John Baron, professor
Hannah Brooke, docent, forskare
Liisa Byberg, professor
Marina Mola Caminal, föreståndare SIMPLER biobank
Carina Fredriksson, forskningssköterska
Emerald Heiland, postdoc
Jonas Höijer, statistiker
Anna-Karin Kolseth, projektkoordinator SIMPLER
Susanna Larsson, docent, universitetslektor
Eva Warensjö Lemming, docent, forskare
Karl Michaëlsson, professor
Erika Olsson, postdoc
Eva Strandberg, forskningssköterska
Bodil Svennblad, statistiker
Stanley Teleka, postdoc
Olga Titova, forskare
Doktorander
Mohammad Kharazmi: Bisphosphonate associated atypical fractures of the human skeleton
Anna Sprinchorn: Peroneus brevis and longus tendon tears – anatomy, injuries and treatment
Avhandlingar
Rui Zheng (2022): Metabolomics, body composition and fracture
Mikael Karlsson (2021): Diet and sarcopenia: Swedish cohort studies in ageing populations
Erika Olsson (2021): Dietary patterns, food groups and vitamin D in relation to dementia, cognitive impairment and Parkinson’s disease
Adam Mitchell (2020): The role of diabetes and glycemic traits in diabetic bone disease
Karl Stattin (2020): Physical activity and risk of fragility fractures
Björn Knutsson (2015): Body mass index and lumbar spinal stenosis
Breiffni Leavy (2015): Fall-Related Hip Fracture: Predisposing and Precipitating Factors
Helena Hallström (2013): Coffee Consumption in Relation to Osteoporosis and Fractures: Observational Studies in Men and Women
Helene Wagner (2012): Genetic and environmental influences on osteoporosis and fractures
Greta Snellman (2011): Boning up on vitamin D: Observational studies on bone and health
Bengt Östman (2009): Influence of oxidative stress on muscle and bone
Hans-Olov Hellström (2007): Bone and aluminium
Kurser och seminarier
Vi ger två årliga kurser på forskarnivå i medicinsk epidemiologi: en på grundläggande nivå (Introduction to epidemiology, 1,5 hp, kursansvarig Hannah Brooke) och en på intermediär till avancerad nivå (Medical epidemiology, 1,5 hp, kursansvarig Liisa Byberg). Med John Baron som huvudlärare erbjuder vi även ytterligare en kurs med inriktning mot klinisk epidemiologi och kliniska prövningar (Clinical Trials Epidemiology, kursansvarig Liisa Byberg). Information om alla våra kurser finns på sidan över kurser vid medicinska fakulteten: http://www2.medfarm.uu.se/utbildning/forskarniva/for_doktorander/kurser.html
Vi anordnar en seminarieserie dit doktorander vid Uppsala universitet är välkomna att diskutera epidemiologisk metod. Deltagande i 10 seminarier ger 1 hp. Mer information och schema för seminarieserien hittar du här (informationen finns endast på engelska).
Nätverk
Vi administrerar ett multidisciplinärt nätverk bestående av epidemiologer vid Uppsala universitet. Nätverket för seniora forskare är för närvarande aktivt endast i formen av en epostlista (du kan anmäla eller avanmäla dig till listan här).
Publikationer
Du hittar alla våra publikationer i Diva, de 50 senaste publikationerna finns listade nedan.
Karl Michaëlsson
Professor vid Institutionen för kirurgiska vetenskaper, Medicinsk epidemiologi
- E-post:
- karl.michaelsson[AT-tecken]uu.se
- Telefon:
- 018-611 9545
50 senaste publikationerna
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A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
Ingår i Clinical Physiology and Functional Imaging, s. 120-127, 2023.
DOI för A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness Ladda ner fulltext (pdf) av A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
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Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study
Ingår i Alimentary Pharmacology and Therapeutics, s. 399-408, 2023.
DOI för Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study Ladda ner fulltext (pdf) av Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study
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Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization
Ingår i BMC Medicine, 2023.
DOI för Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization Ladda ner fulltext (pdf) av Appraising the causal relationship between plasma caffeine levels and neuropsychiatric disorders through Mendelian randomization
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Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
Ingår i Frontiers in Medicine, 2023.
DOI för Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study Ladda ner fulltext (pdf) av Atopic dermatitis and chronic kidney disease: a bidirectional Mendelian randomization study
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Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Ingår i Diabetologia, s. 800-812, 2023.
DOI för Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges Ladda ner fulltext (pdf) av Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
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Circulating proteins and peripheral artery disease risk: observational and Mendelian randomization analyses.
Ingår i European heart journal open, s. oead056-, 2023.
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Depression and 24 gastrointestinal diseases: a Mendelian randomization study
Ingår i Translational Psychiatry, 2023.
DOI för Depression and 24 gastrointestinal diseases: a Mendelian randomization study Ladda ner fulltext (pdf) av Depression and 24 gastrointestinal diseases: a Mendelian randomization study
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Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
Ingår i Cancer Epidemiology, Biomarkers and Prevention, s. 809-817, 2023.
DOI för Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis Ladda ner fulltext (pdf) av Exploring the Complex Relationship between Gut Microbiota and Risk of Colorectal Neoplasia Using Bidirectional Mendelian Randomization Analysis
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Federated analyses of multiple data sources in drug safety studies
Ingår i Pharmacoepidemiology and Drug Safety, s. 279-286, 2023.
DOI för Federated analyses of multiple data sources in drug safety studies Ladda ner fulltext (pdf) av Federated analyses of multiple data sources in drug safety studies
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Field Synopsis of Environmental and Genetic Risk Factors of Sporadic Early-Onset Colorectal Cancer and Advanced Adenoma
Ingår i Cancer Epidemiology, Biomarkers and Prevention, s. 1048-1060, 2023.
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Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
Ingår i Clinical Gastroenterology and Hepatology, s. 398-405.e4, 2023.
DOI för Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease Ladda ner fulltext (pdf) av Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
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Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
Ingår i EBioMedicine, 2023.
DOI för Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases Ladda ner fulltext (pdf) av Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
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Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
Ingår i Journal of the Endocrine Society, 2023.
DOI för Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis Ladda ner fulltext (pdf) av Physical Activity, Sedentary Behavior, and Type 2 Diabetes: Mendelian Randomization Analysis
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Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
Ingår i Nutrition (Burbank, Los Angeles County, Calif.), 2023.
DOI för Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study Ladda ner fulltext (pdf) av Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
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Pre-pregnancy participation and performance in world's largest cross-country ski race as a proxy for physical exercise and fitness, and perinatal outcomes: Prospective registry-based cohort study
Ingår i British Journal of Obstetrics and Gynecology, s. 891-901, 2023.
DOI för Pre-pregnancy participation and performance in world's largest cross-country ski race as a proxy for physical exercise and fitness, and perinatal outcomes: Prospective registry-based cohort study Ladda ner fulltext (pdf) av Pre-pregnancy participation and performance in world's largest cross-country ski race as a proxy for physical exercise and fitness, and perinatal outcomes: Prospective registry-based cohort study
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Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Ingår i Clinical Proteomics, 2023.
DOI för Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases Ladda ner fulltext (pdf) av Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
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Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study
Ingår i Metabolism, 2023.
DOI för Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study Ladda ner fulltext (pdf) av Renoprotective effects of genetically proxied fibroblast growth factor 21: Mendelian randomization, proteome-wide and metabolome-wide association study
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Sleep duration and daytime napping in relation to incident inflammatory bowel disease: a prospective cohort study
Ingår i Alimentary Pharmacology and Therapeutics, s. 475-485, 2023.
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Sleep duration, daytime napping, and risk of peripheral artery disease: multinational cohort and Mendelian randomization studies.
Ingår i European heart journal open, s. oead008-, 2023.
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Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
Ingår i eLIFE, 2023.
DOI för Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis Ladda ner fulltext (pdf) av Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
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Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
Ingår i American Journal of Preventive Medicine, s. 60-66, 2023.
DOI för Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes Ladda ner fulltext (pdf) av Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes
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The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
Ingår i American Journal of Gastroenterology, s. 511-522, 2023.
DOI för The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study Ladda ner fulltext (pdf) av The Contribution of Genetic Risk and Lifestyle Factors in the Development of Adult-Onset Inflammatory Bowel Disease: A Prospective Cohort Study
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The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
Ingår i Scientific Reports, 2023.
DOI för The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men Ladda ner fulltext (pdf) av The metabolomic profiling of total fat and fat distribution in a multi-cohort study of women and men
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Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
Ingår i EBioMedicine, 2023.
DOI för Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses Ladda ner fulltext (pdf) av Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
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Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
Ingår i Clinical Nutrition, s. 1268-1275, 2023.
DOI för Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study Ladda ner fulltext (pdf) av Ultra-processed food intake and incident venous thromboembolism risk: Prospective cohort study
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A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19
Ingår i Scientific Reports, 2022.
DOI för A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19 Ladda ner fulltext (pdf) av A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19
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A posteriori Dietary Patterns in 71-year-old Swedish Men and the Prevalence of Sarcopenia 16 Years Later
Ingår i British Journal of Nutrition, s. 909-920, 2022.
DOI för A posteriori Dietary Patterns in 71-year-old Swedish Men and the Prevalence of Sarcopenia 16 Years Later Ladda ner fulltext (pdf) av A posteriori Dietary Patterns in 71-year-old Swedish Men and the Prevalence of Sarcopenia 16 Years Later
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A Prospective Evaluation of Modifiable Lifestyle Factors in Relation to Peripheral Artery Disease Risk
Ingår i European Journal of Vascular and Endovascular Surgery, s. 83-91, 2022.
DOI för A Prospective Evaluation of Modifiable Lifestyle Factors in Relation to Peripheral Artery Disease Risk Ladda ner fulltext (pdf) av A Prospective Evaluation of Modifiable Lifestyle Factors in Relation to Peripheral Artery Disease Risk
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Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study
Ingår i European Journal of Epidemiology, s. 747-754, 2022.
DOI för Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study Ladda ner fulltext (pdf) av Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study
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Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies
Ingår i European Journal of Epidemiology, s. 655-669, 2022.
DOI för Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies Ladda ner fulltext (pdf) av Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies
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Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
Ingår i Clinical Nutrition, s. 1191-1196, 2022.
DOI för Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies Ladda ner fulltext (pdf) av Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
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Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies
Ingår i EBioMedicine, 2022.
DOI för Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies Ladda ner fulltext (pdf) av Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies
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Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
Ingår i European Journal of Nutrition, s. 3649-3667, 2022.
DOI för Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies. Ladda ner fulltext (pdf) av Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
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Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease: Mendelian Randomization Study
Ingår i Genes, 2022.
DOI för Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease: Mendelian Randomization Study Ladda ner fulltext (pdf) av Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease: Mendelian Randomization Study
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Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
Ingår i Metabolism, 2022.
DOI för Body fatness associations with cancer: evidence from recent epidemiological studies and future directions Ladda ner fulltext (pdf) av Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
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Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study
Ingår i American Journal of Clinical Nutrition, s. 1091-1100, 2022.
DOI för Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study Ladda ner fulltext (pdf) av Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study
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Can Small Amounts of Olive Oil Keep the Death Away?
Ingår i Journal of the American College of Cardiology, s. 113-115, 2022.
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Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
Ingår i Journal of Thrombosis and Thrombolysis, s. 43-50, 2022.
DOI för Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation Ladda ner fulltext (pdf) av Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
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Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study
Ingår i Water Research, 2022.
DOI för Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study Ladda ner fulltext (pdf) av Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study
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Circulating vitamin C and digestive system cancers: Mendelian randomization study
Ingår i Clinical Nutrition, s. 2031-2035, 2022.
DOI för Circulating vitamin C and digestive system cancers: Mendelian randomization study Ladda ner fulltext (pdf) av Circulating vitamin C and digestive system cancers: Mendelian randomization study
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Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study
Ingår i American Journal of Kidney Diseases, s. 9-14.e1, 2022.
DOI för Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study Ladda ner fulltext (pdf) av Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study