The AKI group (Anesthesia, Kidney and Intensive Care)

Robert Frithiof’s Lab

Projects:

Neural and humoral regulation of renal function in perioperative AKI

PhD student: Micael Taavo MD

Postdoc: Stephanie Franzén PhD  

• Sevoflurananestesi minskade urinproduktion via det sympatiska nervsystemet
• Forskningsstudie: Narkosgas kan bidra till nedsatt njurfunktion efter operation 
• Sevoflurananestesi orsakar oliguri, reducerad natriumutsöndring samt ökad reninfrisättning i vuxna patienter som genomgår ryggkirurgi: en randomiserad kontrollerad klinisk studie vid Uppsala universitet och Akademiska sjukhuset
• Role of Renal Sympathetic Nerve Activity in Volatile Anesthesia's Effect on Renal Excretory Function 
• Renal function during sevoflurane or total intravenous propofol anaesthesia: a single-centre parallel randomised controlled study
• Prevention of hemorrhage-induced renal vasoconstriction and hypoxia by angiotensin II type 1 receptor antagonism in pigs
• Pre-treatment with the angiotensin receptor 1 blocker losartan protects renal blood flow and oxygen delivery after propofol-induced hypotension in pigs

PRONMED: The importance of inflammation in acute kidney injury development during severe infections:

PhD student: Sara Bülow Anderberg MD

• Increased levels of plasma cytokines and correlations to organ failure and 30-day mortality in critically ill Covid-19 patients
• Systemic Human Neutrophil Lipocalin Associates with Severe Acute Kidney Injury in SARS-CoV-2 Pneumonia

AKI in sepsis and critically ill COVID-19 patients

PhD student: Tomas Luther MD

• COVID-19 patients in intensive care develop predominantly oliguric acute kidney injury
• Decreased renal perfusion during acute kidney injury in critical COVID-19 assessed by magnetic resonance imaging: a prospective case control study

Intraosseous measurements of oxygen saturation

PhD student: Erik Näslund MD

Pediatric intensive care unit surge capacity in Swedish and Nordic settings

PhD student: Hanna Tegnér

Financing:

Vetenskapsrådet
Magnus Bergvall
ALF-medel Region Uppsala
GA Johanssons
EoR Börjesons
NoRCORP (Nottingham Recovery from COVID19 Research Platform)
Familjen Ernfors fond
Selanders Stiftelse
Njurfonden
Knut och Alice Wallenberg Stiftelse
Hjärtlungfonden
Svenska Läkarsällskapet
Medical Research Council