Cleft and Craniofacial Programme

Principal investigator: Daniel Nowinski

This research programme gathers clinical research projects around two principal problem areas: craniosynostosis and orofacial clefts. Projects around craniosynostosis rest on the platform generated by the national care assignment for craniofacial surgery and are conducted in close collaboration with several departments and units at Uppsala university.

The clinical research deal with various aspects of the congenital conditions  craniosynostosis, craniofacial syndromes and cleft lip and palate deal. The overarching aim of the projects is to gain new knowledge to improve clinical care further. The PI drives projects on surgical outcomes in sagittal craniosynostosis and speech in cleft lip and palate and is a collaborator in projects around brain development/psychiatric outcomes in craniosynostosis and cleft lip and palate, eye function in craniosynostosis, intracranial pressure in craniofacial syndromes, parents’ to children with craniosynostosis perception of care, and optimization of protocols for transfusion and fluid treatment in craniosynostosis surgery.

An experimental research project in collaboration with Oommen Varghese and Jöns Hilborn, Department of Chemistry, Polymer chemistry, Ångström laboratory, aims to develop new technologies for bone regeneration. More specifically, the aim is to combine autologous bone grafting with biodegradable scaffolds, to obtain in situ bone regeneration in cranial defects.