Hyperglycemia and cerebral ischemia

Hyperglycemia is associated with increased complication rate after cardiac surgery and tight glycemic control is established in the postoperative stage. Furthermore, hyperglycemia is particularly harmful to the brain in case of focal ischemia-reperfusion, but to what extent hyperglycemia aggravates the brain damage after cardiac arrest is not clear.

This team investigates the impact of hyperglycemia on ischemic brain injury in terms of focal as well as global insults [1-3]. In 2015, Maria Molnar defended her doctoral thesis, and the current focus is the gene expression profile after hyperglycemic cardiac arrest.  

Publications 

  1. Molnar M, Lennmyr F: Neuroprotection by S-PBN in hyperglycemic ischemic brain injury in rats. Ups J Med Sci 2010, 115(3):163-168.
  2. Lennmyr F, Molnar M, Basu S, Wiklund L: Cerebral effects of hyperglycemia in experimental cardiac arrest. Crit Care Med 2010, 38(8):1726-1732.
  3. Molnar M, Bergquist M, Larsson A, Wiklund L, Lennmyr F: Hyperglycaemia increases S100β after short experimental cardiac arrest. Acta Anaesthesiol Scand. 2014 Jan;58(1):106-13
     

Group members 

Maria Molnar***, Rickard Lindblom, Lars Wiklund***, Fredrik Lennmyr 

*** Collaboration with the department of anesthesiology