Peritoneal carcinomatosis

Principal investigator: Wilhelm Graf, Professor, MD, PhD.
Centre for research and treatment of peritoneal carcinomatosis

The department of Colorectal surgery at Akademiska sjukhuset, Uppsala University Hospital started in the 1990’s with curative treatments for patients with peritoneal carcinomatosis (PC) and was the first institution in the Nordic countries to offer treatment with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). In all, more than 800 patients with PC have been treated at our institution.

The clinical team and research network is multidisciplinary, engaging many departments within the hospital and the university, i.e. surgery, anesthesiology, oncology, radiology, clinical histopathology, clinical pharmacology, nuclear medicine, obstetrics and gynecology, clinical chemistry, Science for Life Laboratory, nursing science, thoracic surgery and the department of psychology.

We collaborate and participate in a network with other hospitals in Sweden offering treatment for PC, these are Stockholm, Gothenburg and Lund university hospitals. This is to secure a uniform selection of patients and standard of care. There is also a close international collaboration with Amsterdam (Antoni van Leeuwenhoek hospital, Nederland cancer institute).

The main aim of the research is to improve the treatment for patients with PC.

In short, we have ongoing studies on these subjects:

  • Prognostic factors using histopathological results and molecular analysis such as microarrays and studies on circulating tumour cells.
  • Epidemiological studies on the potential risk factors for developing PC.
  • Radiological studies to optimize the radiological staging using whole body magnetic resonance imaging (MRI) and positron emission tomography (PET).
  • Studies on morbidities and adverse effects of the CRS and HIPEC.
  • The extent of the resistance of the cytostatic treatment in PC is studied as is the methods to optimize the treatment with warm cytostatic treatment.
  • Furthermore close patient care research (patient empowerment, life quality, psychological effect on patients and relatives).
  • Studies on CRS and HIPEC for ovarian PC.

Research group

Wilhelm Graf, MD, PhD, Professor
Helgi Birgisson, MD, PhD, Associate professor
Ilvars Silins, MD, PhD
Filip Sköldberg, MD, PhD, Post Doc
Lana Ghanipour, MD, PhD, Post Doc
Peter Cashin, MD, PhD, Post Doc
Malin Enblad, MD, PhD Student

Doctoral thesis with focus on peritoneal carcinomatosis performed at our institution:

  1. Håkan Andréasson: Pseudomyxoma peritonei, 2013.
  2. Bo Hultman: Clinical and experimental studies on peritoneal metastases from gastric cancer, 2013.
  3. Peter Cashin: Cytoreductive surgery and intraperitoneal chemotherapy in patients with peritoneal metastases from colorectal cancer, 2012.
  4. Sara Näslund Andréasson. Work Environment in the Operating Room during Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Factors Influencing Choice of Protective Equipment, 2011.
  5. Erebouni Arakelian, Operating Room Efficiency and Postoperative Recovery after Major Abdominal Surgery: The Surgical Team’s Efficiency and the Early Postoperative Recovery of Patients with Peritoneal Carcinomatosis, 2011.
  6. Kurt Van der Speeten MD: A Pharmacokinetic and Pharmacodynamic Rationale for Perioperative Cancer Chemotherapy in Patients with Peritoneal Carcinomatosis, 2010.
  7. Johan Hansson, MD: Loco-regional Treatment of Peritoneal Carcinomatosis: Survival, Morbidity and Quality of Life, 2009.
  8. Haile Mahteme: Hepatic and peritoneal colorectal metastases, 2001.