Medical Epidemiology
The Medical Epidemiology research group is based at the EpiHub (map), an office and network for epidemiological research within the the Disciplinary domain of Medicine and Pharmacy at Uppsala University. This facilitates fruitful interaction with different research groups aiming to jointly build a long term foundation for advanced epidemiological research.

Our main research concern diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well. We combine traditional epidemiological methods with modern causal inference methods in observational studies and perform randomised intervention studies. Find out more about our research by browsing through our publication list.
SIMPLER
Karl Michaëlsson, head of Medical Epidemiology, is also director for the national research infrastructure SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se) and much of our research is based on the cohorts included in SIMPLER. Since the end of 2018 the infrastructure is managed by a consortium consisting of Uppsala University, Karolinska Institutet, Chalmers University of Technology and Örebro University in collaboration with the County Councils in Uppsala, Västmanland and Örebro County.
The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.
Funding
The research group has received funding from the Swedish Research Council (VR), the Swedish Research Council for Health, Working Life and Welfare (FORTE), the Swedish Heart-Lung Foundation, the Swedish Cancer Society, Hjärnfonden, and ALF.
Members of the group
The Medical Epidemiology research group is headed by Karl Michaëlsson, Professor of Medical Epidemiology and Senior Consultant in Orthopaedic Surgery.
Group members (contact information)
John Baron, professor
Hannah Brooke, associate professor, researcher
Liisa Byberg, professor
Marina Mola Caminal, biobank manager
Carina Fredriksson, research nurse
Emerald Heiland, postdoc
Jonas Höijer, statistician
Anna-Karin Kolseth, project coordinator SIMPLER
Susanna Larsson, associate professor, senior lecturer
Eva Warensjö Lemming, associate professor, researcher
Karl Michaëlsson, professor
Erika Olsson, postdoc
Eva Strandberg, research nurse
Bodil Svennblad, statistician
Stanley Teleka, postdoc
Olga Titova, researcher
PhD students
Mohammad Kharazmi: Bisphosphonate associated atypical fractures of the human skeleton
Anna Sprinchorn: Peroneus brevis and longus tendon tears – anatomy, injuries and treatment
Theses
Rui Zheng (2022): Metabolomics, body composition and fracture
Mikael Karlsson (2021): Diet and sarcopenia: Swedish cohort studies in ageing populations
Erika Olsson (2021): Dietary patterns, food groups and vitamin D in relation to dementia, cognitive impairment and Parkinson’s disease
Adam Mitchell (2020): The role of diabetes and glycemic traits in diabetic bone disease
Karl Stattin (2020): Physical activity and risk of fragility fractures
Björn Knutsson (2015): Body mass index and lumbar spinal stenosis
Breiffni Leavy (2015): Fall-Related Hip Fracture: Predisposing and Precipitating Factors
Helena Hallström (2013): Coffee Consumption in Relation to Osteoporosis and Fractures: Observational Studies in Men and Women
Helene Wagner (2012): Genetic and environmental influences on osteoporosis and fractures
Greta Snellman (2011): Boning up on vitamin D: Observational studies on bone and health
Bengt Östman (2009): Influence of oxidative stress on muscle and bone
Hans-Olov Hellström (2007): Bone and aluminium
CourseS AND seminars
We are giving two annual research training courses in medical epidemiology: a basic level course (Introduction to epidemiology, 1.5 hp, course leader Hannah Brooke) and a course at an intermediate to advanced level (Medical epidemiology, 1.5 hp, course leader Liisa Byberg). With Prof John Baron as main teacher we provide an additional course aimed at clinical epidemiology and clinical trials (Clinical Trials Epidemiology, course leader Liisa Byberg). Information on the courses is available at: http://www2.medfarm.uu.se/utbildning/forskarniva/for_doktorander/kurser.html
We host methodological seminars aimed at PhD stuents at Uppsala University. Attendance to 10 seminars merits 1 hp. The schedule and information on the seminars (and how to subscribe to the email list) can be found here.
NETWORK AND SEMINARS
We administrate a multidisciplinary network of epidemiologists at Uppsala University. The Network for senior resarchers is at the moment active only in the form of an email list (subscribe or unsubscribe here).
Publications
All publications can be viewed in Diva, the 50 most recent publications are listed below.
Karl Michaëlsson
Professor at Department of Surgical Sciences, Medical epidemiology
- Email:
- Karl.Michaelsson[AT-sign]surgsci.uu.se
- Telephone:
- +4618-6119545
50 most recent publications
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A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
Part of Clinical Physiology and Functional Imaging, p. 120-127, 2023.
DOI for A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness Download full text (pdf) of A detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness
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Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study
Part of Alimentary Pharmacology and Therapeutics, p. 399-408, 2023.
DOI for Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study Download full text (pdf) of Antioxidants, minerals and vitamins in relation to Crohn's disease and ulcerative colitis: A Mendelian randomization study
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Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
Part of Diabetologia, p. 800-812, 2023.
DOI for Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges Download full text (pdf) of Causal factors underlying diabetes risk informed by Mendelian randomisation analysis: evidence, opportunities and challenges
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Federated analyses of multiple data sources in drug safety studies
Part of Pharmacoepidemiology and Drug Safety, p. 279-286, 2023.
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Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
Part of Clinical Gastroenterology and Hepatology, p. 398-405.e4, 2023.
DOI for Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease Download full text (pdf) of Inverse Association Between Serum 25-Hydroxyvitamin D and Nonalcoholic Fatty Liver Disease
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Mendelian randomization and clinical trial evidence supports TYK2 inhibition as a therapeutic target for autoimmune diseases
Part of EBioMedicine, 2023.
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Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
Part of Nutrition (Burbank, Los Angeles County, Calif.), 2023.
DOI for Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study Download full text (pdf) of Plasma phospholipid arachidonic acid in relation to non-alcoholic fatty liver disease: Mendelian randomization study
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Sleep duration and daytime napping in relation to incident inflammatory bowel disease: a prospective cohort study
Part of Alimentary Pharmacology and Therapeutics, p. 475-485, 2023.
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Sleep duration, daytime napping, and risk of peripheral artery disease: multinational cohort and Mendelian randomization studies.
Part of European heart journal open, p. oead008-, 2023.
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Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
Part of eLIFE, 2023.
DOI for Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis Download full text (pdf) of Smoking, alcohol consumption, and 24 gastrointestinal diseases: Mendelian randomization analysis
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Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes.
Part of American Journal of Preventive Medicine, 2023.
DOI for Swedish Snuff (Snus), Cigarette Smoking, and Risk of Type 2 Diabetes.
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Therapeutic targets for inflammatory bowel disease: proteome-wide Mendelian randomization and colocalization analyses
Part of EBioMedicine, 2023.
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A Mendelian randomization study of genetic predisposition to autoimmune diseases and COVID-19
Part of Scientific Reports, 2022.
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A posteriori Dietary Patterns in 71-year-old Swedish Men and the Prevalence of Sarcopenia 16 Years Later
Part of British Journal of Nutrition, p. 909-920, 2022.
DOI for A posteriori Dietary Patterns in 71-year-old Swedish Men and the Prevalence of Sarcopenia 16 Years Later Download full text (pdf) of A posteriori Dietary Patterns in 71-year-old Swedish Men and the Prevalence of Sarcopenia 16 Years Later
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A Prospective Evaluation of Modifiable Lifestyle Factors in Relation to Peripheral Artery Disease Risk
Part of European Journal of Vascular and Endovascular Surgery, p. 83-91, 2022.
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Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study
Part of European Journal of Epidemiology, p. 747-754, 2022.
DOI for Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study Download full text (pdf) of Adiposity, diabetes, lifestyle factors and risk of gastroesophageal reflux disease: a Mendelian randomization study
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Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies
Part of European Journal of Epidemiology, p. 655-669, 2022.
DOI for Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies Download full text (pdf) of Alcohol consumption in relation to cardiovascular diseases and mortality: a systematic review of Mendelian randomization studies
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Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
Part of Clinical Nutrition, p. 1191-1196, 2022.
DOI for Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies Download full text (pdf) of Anti-inflammatory diet and incident peripheral artery disease: Two prospective cohort studies
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Appraising the causal role of smoking in multiple diseases: A systematic review and meta-analysis of Mendelian randomization studies
Part of EBioMedicine, 2022.
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Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
Part of European Journal of Nutrition, p. 3649-3667, 2022.
DOI for Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies. Download full text (pdf) of Associations between exploratory dietary patterns and incident type 2 diabetes: a federated meta-analysis of individual participant data from 25 cohort studies.
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Bidirectional Association between Major Depressive Disorder and Gastroesophageal Reflux Disease: Mendelian Randomization Study
Part of Genes, 2022.
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Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
Part of Metabolism, 2022.
DOI for Body fatness associations with cancer: evidence from recent epidemiological studies and future directions Download full text (pdf) of Body fatness associations with cancer: evidence from recent epidemiological studies and future directions
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Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study
Part of American Journal of Clinical Nutrition, p. 1091-1100, 2022.
DOI for Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study Download full text (pdf) of Calcium and magnesium in drinking water and risk of myocardial infarction and stroke-a population-based cohort study
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Can Small Amounts of Olive Oil Keep the Death Away?
Part of Journal of the American College of Cardiology, p. 113-115, 2022.
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Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
Part of Journal of Thrombosis and Thrombolysis, p. 43-50, 2022.
DOI for Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation Download full text (pdf) of Causal effect of renal function on venous thromboembolism: a two-sample Mendelian randomization investigation
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Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study
Part of Water Research, 2022.
DOI for Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study Download full text (pdf) of Chlorination by-products in drinking water and risk of bladder cancer - A population-based cohort study
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Circulating vitamin C and digestive system cancers: Mendelian randomization study
Part of Clinical Nutrition, p. 2031-2035, 2022.
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Coffee and Caffeine Consumption and Risk of Kidney Stones: A Mendelian Randomization Study
Part of American Journal of Kidney Diseases, p. 9-14.e1, 2022.
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Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs
Part of BMJ Open, 2022.
DOI for Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs Download full text (pdf) of Cohort profile: the Swedish study of SUDden cardiac Death in the Young (SUDDY) 2000-2010: a complete nationwide cohort of SCDs
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Decompression alone or decompression with fusion for lumbar spinal stenosis: a randomized clinical trial with two-year MRI follow-up
Part of The Bone & Joint Journal, p. 1343-1351, 2022.
DOI for Decompression alone or decompression with fusion for lumbar spinal stenosis: a randomized clinical trial with two-year MRI follow-up Download full text (pdf) of Decompression alone or decompression with fusion for lumbar spinal stenosis: a randomized clinical trial with two-year MRI follow-up
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Differentiating Associations of Glycemic Traits With Atherosclerotic and Thrombotic Outcomes: Mendelian Randomization Investigation
Part of Diabetes, p. 2222-2232, 2022.
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Effect of a diet rich in galactose or fructose, with or without fructooligosaccharides, on gut microbiota composition in rats
Part of Frontiers in Nutrition, 2022.
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Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
Part of Diabetes, p. 329-339, 2022.
DOI for Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study Download full text (pdf) of Effect of General Adiposity and Central Body Fat Distribution on the Circulating Metabolome: A Multi-Cohort Nontargeted Metabolomics Observational and Mendelian Randomization Study
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Family History and Warning Symptoms Precede Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy (From A Nationwide Study in Sweden)
Part of American Journal of Cardiology, p. 124-130, 2022.
DOI for Family History and Warning Symptoms Precede Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy (From A Nationwide Study in Sweden) Download full text (pdf) of Family History and Warning Symptoms Precede Sudden Cardiac Death in Arrhythmogenic Right Ventricular Cardiomyopathy (From A Nationwide Study in Sweden)
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Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness
Part of European heart journal open, 2022.
DOI for Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness Download full text (pdf) of Fatty acid desaturase genetic variations and dietary omega-3 fatty acid intake associate with arterial stiffness
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GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis
Part of Frontiers in Genetics, 2022.
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Genetic Liability to Rheumatoid Arthritis in Relation to Coronary Artery Disease and Stroke Risk
Part of Arthritis & Rheumatology, p. 1638-1647, 2022.
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Genetically Predicted Adiposity, Diabetes, and Lifestyle Factors in Relation to Diverticular Disease
Part of Clinical Gastroenterology and Hepatology, p. 1077-1084, 2022.
DOI for Genetically Predicted Adiposity, Diabetes, and Lifestyle Factors in Relation to Diverticular Disease Download full text (pdf) of Genetically Predicted Adiposity, Diabetes, and Lifestyle Factors in Relation to Diverticular Disease
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Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study
Part of Nutrients, p. 509-, 2022.
DOI for Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study Download full text (pdf) of Genetically Predicted Circulating Copper and Risk of Chronic Kidney Disease: A Mendelian Randomization Study
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Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries
Part of eLIFE, 2022.
DOI for Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries Download full text (pdf) of Genetically predicted high IGF-1 levels showed protective effects on COVID-19 susceptibility and hospitalization: a Mendelian randomisation study with data from 60 studies across 25 countries
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Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.
Part of International Journal of Epidemiology, p. 1931-1942, 2022.
DOI for Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation. Download full text (pdf) of Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation.