Medical Epidemiology

Medical epidemiology research aims at evaluating treatments of diseases and at investigating the importance of genes and lifestyle for development of diseases. Common to epidemiological research is that we observe and quantify associations, usually without performing interventions among the study participants.

The Medical Epidemiology research group is based at the EpiHub (map), an office and network for epidemiological research within the the Disciplinary domain of Medicine and Pharmacy at Uppsala University. This facilitates fruitful interaction with different research groups aimping to jointly build a long term foundation for advanced epidemioloigcal research.

Hip fracture. Photo: Karl Michaëlsson
Hip fracture. Photo: Karl Michaëlsson

We also collaborate with external epidemiological, nutritional, genetic, cardiovascular, injury, osteoporosis and bone density expertise. Our main research topics concerns diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well.

Network and Seminars

We administrate a multidisciplinary network of epidemiologists at Uppsala University. The Network for senior resarchers is at the moment active only in the form of an email list (subscribe or unsubscribe here). We arrange methodological seminars aimed at PhD stuents at Uppsala University that are given as a course. The schedule and information on the seminars (and how to subscribe to the email list) can be found here.  

SIMPLER

Karl Michaëlsson, head of Medical Epidemiology, is also director for the national research infrastructure SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se) and much of our research is based on the cohorts included in SIMPLER. 

The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.

Since the end of 2018 the infrastructure is managed by a consortium consisting of Uppsala University, Karolinska Institutet, Chalmers University of Technology and Örebro University in collaboration with the County Councils in Uppsala, Västmanland and Örebro County. Read more on the SIMPLER website: simpler4health.se.

Other cohorts

Other long-lasting projects with our involvement are

  • ULSAM
  • EpiHealth
  • PIVUS
  • the cohort from the ski race Vasaloppet
  • UK Biobank
  • FinnGen
  • Uppsala Family Study
  • The MEGASTROKE consortium 
  • The Intracerebral Hemorrhage Genetics Collaboration and International Stroke Genetics Consortium 
  • CARDIoGRAMplusC4D consortium
  • HERMES consortium
  • AFGen consortium
  • AAAGen consortium 

Funding

The Swedish Research Council (VR), the Swedish Research Council for Health, Working Life and Welfare (FORTE), the Swedish Heart-Lung Foundation, and ALF.

Members of the group

Headed by Karl Michaëlsson, Professor of Medical Epidemiology and Senior Consultant in Orthopaedic Surgery. Contact information.

Employees

John Baron, Professor
Hannah Brooke, Postdoc
Liisa Byberg, Associate Professor in Medical Epidemiology, Senior lecturer
Marina Mola Caminal, Research assistant
Rachel Delicano, Research assistant
Carina Fredriksson, Research Nurse
Jonas Höijer, Statistician
Anna-Karin Kolseth, Project coordinator SIMPLER
Susanna Larsson, Associate Professor, Senior lecturer
Eva Warensjö Lemming, Associate Professor in Medical Epidemiology, Researcher
Eva Strandberg, Research Nurse
Bodil Svennblad, Statistician
Olga Titova, Postdoc
Alicja Wolk, Professor

PhD students

Mikael Karlsson: Diet and sarcopenia
Mohammad Kharazmi: Bisphosphonate associated atypical fractures of the human skeleton
Erika Olsson: Dietary patterns, food groups and vitamin D in relation to dementia, cognitive
impairment and Parkinson’s disease
Anna Sprinchorn: Peroneus brevis and longus tendon tears – anatomy, injuries and treatment
Rui Zheng: Large scale metabolomic profiling for precision medicine and nutrition

Theses

Adam Mitchell (2020): The role of diabetes and glycemic traits in diabetic bone disease
Karl Stattin (2020): Physical activity and risk of fragility fractures
Björn Knutsson (2015): Body mass index and lumbar spinal stenosis 
Breiffni Leavy (2015): Fall-Related Hip Fracture: Predisposing and Precipitating Factors
Helena Hallström (2013): Coffee Consumption in Relation to Osteoporosis and Fractures: Observational Studies in Men and Women 
Helene Wagner (2012): Genetic and environmental influences on osteoporosis and fractures
Greta Snellman (2011): Boning up on vitamin D: Observational studies on bone and health 
Bengt Östman (2009): Influence of oxidative stress on muscle and bone 
Hans-Olov Hellström (2007): Bone and aluminium 

CourseS

We are giving two annual research training courses in medical epidemiology: a basic level course (Introduction to epidemiology) and a course at an intermediate to advanced level (Medical epidemiology). With Prof John Baron as main teacher we provide an additional course aimed at clinical epidemiology and clinical trials (Clinical Trials Epidemiology). Information on the courses can be found at http://www2.medfarm.uu.se/utbildning/forskarniva/for_doktorander/kurser.html

Publications

View our publications in Diva. The 50 most recent publications are listed below.

Karl Michaëlsson

Professor at Department of Surgical Sciences, Medical epidemiology

Email:
Karl.Michaelsson[AT-sign]surgsci.uu.se
Telephone:
+4618-6119545

Publications

  • Iversen, Kia Nøhr; Carlsson, Frida; Andersson, Agneta; Michaëlsson, Karl et al.

    A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)

    Part of Clinical Nutrition, p. 155-169, 2021.

  • Karlsson, Mikael; Becker, Wulf; Cederholm, Tommy; Byberg, Liisa

    A posteriori Dietary Patterns in 71-year old Swedish Men and the Prevalence of Sarcopenia 16 Years Later

    Part of British Journal of Nutrition, p. 1-28, 2021.

  • Ludvigsson, Jonas F.; Appelros, Peter; Askling, Johan; Byberg, Liisa et al.

    Adaptation of the Charlson Comorbidity Index for Register-Based Research in Sweden

    Part of Clinical Epidemiology, p. 21-41, 2021.

    Open access
  • Yuan, Shuai; Xiong, Ying; Larsson, Susanna C.

    An atlas on risk factors for multiple sclerosis: a Mendelian randomization study.

    Part of Journal of Neurology, p. 114-124, 2021.

    Open access
  • Yuan, Shuai; Vithayathil, Mathew; Kar, Siddhartha; Carter, Paul et al.

    Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis

    Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1559-1562, 2021.

    Open access
  • Enarsson, Malin; Feldreich, Tobias; Byberg, Liisa; Nowak, Christoph et al.

    Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study

    Part of SPORTS MEDICINE-OPEN, 2021.

    Open access
  • Larsson, Susanna C.; Gill, Dipender

    Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study

    Part of Neurology, p. E341-E344, 2021.

    Open access
  • Vithayathil, Mathew; Carter, Paul; Kar, Siddhartha; Mason, Amy M. et al.

    Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study

    Part of PLoS Medicine, 2021.

    Open access
  • Lind, Lars; Zethelius, Björn; Lindberg, Eva; Pedersen, Nancy L. et al.

    Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies

    Part of PLOS ONE, 2021.

    Open access
  • Michaëlsson, Karl; Larsson, Susanna C.

    Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study

    Part of Nutrients, 2021.

    Open access
  • Fu, Yuanqing; Xu, Fengzhe; Jiang, Longda; Miao, Zelei et al.

    Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study

    Part of BMC Medicine, 2021.

    Open access
  • Yuan, Shuai; Carter, Paul; Mason, Amy M.; Burgess, Stephen et al.

    Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study

    Part of Nutrients, 2021.

    Open access
  • Warensjö Lemming, Eva; Byberg, Liisa; Höijer, Jonas; Larsson, Susanna C. et al.

    Combinations of dietary calcium intake and mediterranean-style diet on risk of hip fracture: A longitudinal cohort study of 82,000 women and men

    Part of Clinical Nutrition, p. 4161-4170, 2021.

    Open access
  • Wu, You; Huang, Ruyi; Wang, Molin; Bernstein, Leslie et al.

    Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies

    Part of American Journal of Clinical Nutrition, p. 450-461, 2021.

  • Mhd Omar, Nor Adila; Frank, Jan; Kruger, Johanita; Dal Bello, Federica et al.

    Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model

    Part of Molecular Nutrition & Food Research, 2021.

    Open access
  • Yuan, Shuai; Ming-wei, Liu; Qi-qiang, He; Larsson, Susanna C.

    Egg, cholesterol and protein intake and incident type 2 diabetes mellitus: Results of repeated measurements from a prospective cohort study

    Part of Clinical Nutrition, p. 4180-4186, 2021.

  • Mitchell, Adam; Larsson, Susanna C.; Fall, Tove; Melhus, Håkan et al.

    Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study

    Part of Diabetologia, p. 1348-1357, 2021.

    Open access
  • Helte, Emilie; Donat Vargas, Carolina; Kippler, Maria; Wolk, Alicja et al.

    Fluoride in Drinking Water, Diet, and Urine in Relation to Bone Mineral Density and Fracture Incidence in Postmenopausal Women

    Part of Journal of Environmental Health Perspectives, 2021.

    Open access
  • Baxter, Joseph S.; Johnson, Nichola; Tomczyk, Katarzyna; Gillespie, Andrea et al.

    Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element

    Part of American Journal of Human Genetics, p. 1190-1203, 2021.

    Open access
  • Yuan, Shuai; Giovannucci, Edward L.; Larsson, Susanna C.

    Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study

    Part of NPJ GENOMIC MEDICINE, 2021.

    Open access
  • Larsson, Susanna C.; Gill, Dipender

    Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer's Disease

    Part of Nutrients, 2021.

    Open access
  • Yuan, Shuai; Mason, Amy M.; Burgess, Stephen; Larsson, Susanna C.

    Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study

    Part of European Journal of Epidemiology, p. 393-400, 2021.

    Open access
  • Larsson, Susanna C.; Gill, Dipender

    Genetic predisposition to allergic diseases is inversely associated with risk of COVID-19

    Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1911-1913, 2021.

    Open access
  • Yuan, Shuai; Carter, Paul; Vithayathil, Mathew; Kar, Siddhartha et al.

    Genetically predicted circulating B vitamins in relation to digestive system cancers

    Part of British Journal of Cancer, p. 1997-2003, 2021.

    Open access
  • Yuan, Shuai; Xiong, Ying; Michaelsson, Madeleine; Michaëlsson, Karl et al.

    Genetically predicted education attainment in relation to somatic and mental health

    Part of Scientific Reports, 2021.

    Open access
  • Larsson, Susanna C.; Carter, Paul; Vithayathil, Mathew; Mason, Amy M. et al.

    Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: A mendelian randomization study

    Part of Clinical Nutrition, p. 3332-3337, 2021.

    Open access
  • Yuan, Shuai; Burgess, Stephen; Laffan, Mike; Mason, Amy M. et al.

    Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study

    Part of Journal of the American Heart Association, 2021.

    Open access
  • Larsson, Susanna C.; Burgess, Stephen; Gill, Dipender

    Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia

    Part of European Respiratory Journal, 2021.

    Open access
  • Grauman, Åsa; Veldwijk, Jorien; Stefan, James; Hansson, Mats et al.

    Good general health and lack of family history influence the underestimation of cardiovascular risk: A cross sectional study

    Part of European Journal of Cardiovascular Nursing, 2021.

    Open access
  • Yuan, Shuai; Mason, Amy M.; Carter, Paul; Burgess, Stephen et al.

    Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study

    Part of BMC Medicine, 2021.

    Open access
  • Bernhoff, Karin; Michaëlsson, Karl; Björck, Martin

    Incidence and Outcome of Popliteal Artery Injury Associated with Knee Dislocations, Ligamentous Injuries, and Close to Knee Fractures: A Nationwide Population Based Cohort Study

    Part of European Journal of Vascular and Endovascular Surgery, p. 297-304, 2021.

    Open access
  • Yuan, Shuai; Wan, Zi-Hao; Cheng, Shi-Le; Michaëlsson, Karl et al.

    Insulin-like Growth Factor-1, Bone Mineral Density, and Fracture: A Mendelian Randomization Study

    Part of Journal of Clinical Endocrinology and Metabolism, p. E1552-E1558, 2021.

    Open access
  • Mitchell, Adam; Fall, Tove; Melhus, Håkan; Wolk, Alicja et al.

    Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?

    Part of International Journal of Epidemiology, p. 234-244, 2021.

    Open access
  • Yuan, Shuai; Bruzelius, Maria; Hakansson, Niclas; Akesson, Agneta et al.

    Lifestyle factors and venous thromboembolism in two cohort studies

    Part of Thrombosis Research, p. 119-124, 2021.

    Open access
  • Larsson, Susanna C.

    Mendelian randomization as a tool for causal inference in human nutrition and metabolism

    Part of Current Opinion in Lipidology, p. 1-8, 2021.

  • Yuan, Shuai; Tomson, Torbjorn; Larsson, Susanna C.

    Modifiable risk factors for epilepsy: A two-sample Mendelian randomization study

    Part of Brain and Behavior, 2021.

    Open access
  • Yuan, Shuai; Bruzelius, Maria; Xiong, Ying; Håkansson, Niclas et al.

    Overall and abdominal obesity in relation to venous thromboembolism

    Part of Journal of Thrombosis and Haemostasis, p. 460-469, 2021.

    Open access
  • Zheng, Rui; Byberg, Liisa; Larsson, Susanna C.; Höijer, Jonas et al.

    Prior loss of body mass index, low body mass index, and central obesity independently contribute to higher rates of fractures in elderly women and men

    Part of Journal of Bone and Mineral Research, p. 1288-1299, 2021.

    Open access
  • Titova, Olga E; Michaëlsson, Karl; Vithayathil, Mathew; Mason, Amy M et al.

    Sleep duration and risk of overall and 22 site-specific cancers: A Mendelian randomization study

    Part of International Journal of Cancer, p. 914-920, 2021.

    Open access
  • Titova, Olga E; Baron, John A.; Michaëlsson, Karl; Larsson, Susanna C.

    Swedish snuff (snus) and risk of cardiovascular disease and mortality: prospective cohort study of middle-aged and older individuals

    Part of BMC Medicine, 2021.

    Open access
  • Høyer, Anne; Christensen, Jacob Juel; Arnesen, Erik Kristoffer; Andersen, Rikke et al.

    The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews

    2021.

  • Mitchell, Adam; Fall, Tove; Melhus, Håkan; Lind, Lars et al.

    Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women: Supplementary material

    2021.

    Open access
  • Mitchell, Adam; Fall, Tove; Melhus, Håkan; Lind, Lars et al.

    Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years

    Part of Journal of Clinical Endocrinology and Metabolism, 2021.

  • Gill, Dipender; Arvanitis, Marios; Carter, Paul; Cordero, Ana I. Hernandez et al.

    ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study

    Part of Royal Society Open Science, 2020.

    Open access
  • Larsson, Susanna C.; Burgess, Stephen; Mason, Amy M.; Michaëlsson, Karl

    Alcohol Consumption and Cardiovascular Disease A Mendelian Randomization Study

    Part of Circulation, p. 121-127, 2020.

    Open access
  • Matthews, Charles E.; Moore, Steven C.; Arem, Hannah; Cook, Michael B. et al.

    Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk

    Part of Journal of Clinical Oncology, p. 686-697, 2020.

    Open access
  • Yuan, Shuai; Larsson, Susanna C.

    An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study.

    Part of Diabetologia, p. 2359-2371, 2020.

    Open access
  • Kaluza, Joanna; Levitan, Emily B.; Michaëlsson, Karl; Wolk, Alicja

    Anti-inflammatory diet and risk of heart failure: two prospective cohort studies

    Part of European Journal of Heart Failure, p. 676-682, 2020.

  • van Oort, Sabine; Beulens, Joline W. J.; van Ballegooijen, Adriana J.; Grobbee, Diederick E. et al.

    Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension: A Mendelian Randomization Study

    Part of Hypertension, p. 1971-1979, 2020.

    Open access
  • Yuan, Shuai; Larsson, Susanna C.

    Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study

    Part of Diabetologia, p. 116-123, 2020.

    Open access
Last modified: 2021-05-03