Medical epidemiology research aims at evaluating treatments of diseases and at investigating the importance of genes and lifestyle for development of diseases. Common to epidemiological research is that we observe and quantify associations, usually without performing interventions among the study participants.
The Medical Epidemiology research group is based at the EpiHub (map), an office and network for epidemiological research within the the Disciplinary domain of Medicine and Pharmacy at Uppsala University. This facilitates fruitful interaction with different research groups aimping to jointly build a long term foundation for advanced epidemioloigcal research.
We also collaborate with external epidemiological, nutritional, genetic, cardiovascular, injury, osteoporosis and bone density expertise. Our main research topics concerns diseases and conditions in the ageing population, including fragility fractures, cardiovascular diseases and cancer, but we are involved in other areas of epidemiological research as well.
Network and Seminars
We administrate a multidisciplinary network of epidemiologists at Uppsala University. The Network for senior resarchers is at the moment active only in the form of an email list (subscribe or unsubscribe here). We arrange methodological seminars aimed at PhD stuents at Uppsala University that are given as a course. The schedule and information on the seminars (and how to subscribe to the email list) can be found here.
Karl Michaëlsson, head of Medical Epidemiology, is also director for the national research infrastructure SIMPLER, Swedish Infrastructure for Medical Population-Based Life-Course and Environmental Research (simpler4health.se) and much of our research is based on the cohorts included in SIMPLER.
The infrastructure's mission is to provide national and international researchers with data for studies on how dietary and lifestyle factors and genetics affect our health, especially during the latter part of life. The knowledge can for example be used to develop recommendations on diet and lifestyle, develop new markers fore easier and more accurate diagnosis of chronic diseases and their precursors and to develop new individualized treatments.
Since the end of 2018 the infrastructure is managed by a consortium consisting of Uppsala University, Karolinska Institutet, Chalmers University of Technology and Örebro University in collaboration with the County Councils in Uppsala, Västmanland and Örebro County. Read more on the SIMPLER website: simpler4health.se.
Other long-lasting projects with our involvement are
- the cohort from the ski race Vasaloppet
- UK Biobank
- Uppsala Family Study
- The MEGASTROKE consortium
- The Intracerebral Hemorrhage Genetics Collaboration and International Stroke Genetics Consortium
- CARDIoGRAMplusC4D consortium
- HERMES consortium
- AFGen consortium
- AAAGen consortium
The Swedish Research Council (VR), the Swedish Research Council for Health, Working Life and Welfare (FORTE), the Swedish Heart-Lung Foundation, and ALF.
Members of the group
Headed by Karl Michaëlsson, Professor of Medical Epidemiology and Senior Consultant in Orthopaedic Surgery. Contact information.
John Baron, Professor
Hannah Brooke, Postdoc
Liisa Byberg, Associate Professor in Medical Epidemiology, Senior lecturer
Marina Mola Caminal, Research assistant
Rachel Delicano, Research assistant
Carina Fredriksson, Research Nurse
Jonas Höijer, Statistician
Anna-Karin Kolseth, Project coordinator SIMPLER
Susanna Larsson, Associate Professor, Senior lecturer
Eva Warensjö Lemming, Associate Professor in Medical Epidemiology, Researcher
Eva Strandberg, Research Nurse
Bodil Svennblad, Statistician
Olga Titova, Postdoc
Alicja Wolk, Professor
Mikael Karlsson: Diet and sarcopenia
Mohammad Kharazmi: Bisphosphonate associated atypical fractures of the human skeleton
Erika Olsson: Dietary patterns, food groups and vitamin D in relation to dementia, cognitive
impairment and Parkinson’s disease
Anna Sprinchorn: Peroneus brevis and longus tendon tears – anatomy, injuries and treatment
Rui Zheng: Large scale metabolomic profiling for precision medicine and nutrition
Adam Mitchell (2020): The role of diabetes and glycemic traits in diabetic bone disease
Karl Stattin (2020): Physical activity and risk of fragility fractures
Björn Knutsson (2015): Body mass index and lumbar spinal stenosis
Breiffni Leavy (2015): Fall-Related Hip Fracture: Predisposing and Precipitating Factors
Helena Hallström (2013): Coffee Consumption in Relation to Osteoporosis and Fractures: Observational Studies in Men and Women
Helene Wagner (2012): Genetic and environmental influences on osteoporosis and fractures
Greta Snellman (2011): Boning up on vitamin D: Observational studies on bone and health
Bengt Östman (2009): Influence of oxidative stress on muscle and bone
Hans-Olov Hellström (2007): Bone and aluminium
We are giving two annual research training courses in medical epidemiology: a basic level course (Introduction to epidemiology) and a course at an intermediate to advanced level (Medical epidemiology). With Prof John Baron as main teacher we provide an additional course aimed at clinical epidemiology and clinical trials (Clinical Trials Epidemiology). Information on the courses can be found at http://www2.medfarm.uu.se/utbildning/forskarniva/for_doktorander/kurser.html
View our publications in Diva. The 50 most recent publications are listed below.
A hypocaloric diet rich in high fiber rye foods causes greater reduction in body weight and body fat than a diet rich in refined wheat: A parallel randomized controlled trial in adults with overweight and obesity (the RyeWeight study)
Part of Clinical Nutrition, p. 155-169, 2021.
A posteriori Dietary Patterns in 71-year old Swedish Men and the Prevalence of Sarcopenia 16 Years Later
Part of British Journal of Nutrition, p. 1-28, 2021.
Adaptation of the Charlson Comorbidity Index for Register-Based Research in Sweden
Part of Clinical Epidemiology, p. 21-41, 2021.
An atlas on risk factors for multiple sclerosis: a Mendelian randomization study.
Part of Journal of Neurology, p. 114-124, 2021.
Assessing the protective role of allergic disease in gastrointestinal tract cancers using Mendelian randomization analysis
Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1559-1562, 2021.
Association between Cardiorespiratory Fitness and Circulating Proteins in 50-Year-Old Swedish Men and Women: a Cross-Sectional Study
Part of SPORTS MEDICINE-OPEN, 2021.
Association of Serum Magnesium Levels With Risk of Intracranial Aneurysm: A Mendelian Randomization Study
Part of Neurology, p. E341-E344, 2021.
Body size and composition and risk of site-specific cancers in the UK Biobank and large international consortia: A mendelian randomisation study
Part of PLoS Medicine, 2021.
Changes in leisure-time physical activity during the adult life span and relations to cardiovascular risk factors-Results from multiple Swedish studies
Part of PLOS ONE, 2021.
Circulating Alpha-Tocopherol Levels, Bone Mineral Density, and Fracture: Mendelian Randomization Study
Part of Nutrients, 2021.
Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study
Part of BMC Medicine, 2021.
Coffee Consumption and Cardiovascular Diseases: A Mendelian Randomization Study
Part of Nutrients, 2021.
Combinations of dietary calcium intake and mediterranean-style diet on risk of hip fracture: A longitudinal cohort study of 82,000 women and men
Part of Clinical Nutrition, p. 4161-4170, 2021.
Dairy foods, calcium, and risk of breast cancer overall and for subtypes defined by estrogen receptor status: a pooled analysis of 21 cohort studies
Part of American Journal of Clinical Nutrition, p. 450-461, 2021.
Effects of High Intakes of Fructose and Galactose, with or without Added Fructooligosaccharides, on Metabolic Factors, Inflammation, and Gut Integrity in a Rat Model
Part of Molecular Nutrition & Food Research, 2021.
Egg, cholesterol and protein intake and incident type 2 diabetes mellitus: Results of repeated measurements from a prospective cohort study
Part of Clinical Nutrition, p. 4180-4186, 2021.
Fasting glucose, bone area and bone mineral density: a Mendelian randomisation study
Part of Diabetologia, p. 1348-1357, 2021.
Fluoride in Drinking Water, Diet, and Urine in Relation to Bone Mineral Density and Fracture Incidence in Postmenopausal Women
Part of Journal of Environmental Health Perspectives, 2021.
Functional annotation of the 2q35 breast cancer risk locus implicates a structural variant in influencing activity of a long-range enhancer element
Part of American Journal of Human Genetics, p. 1190-1203, 2021.
Gallstone disease, diabetes, calcium, triglycerides, smoking and alcohol consumption and pancreatitis risk: Mendelian randomization study
Part of NPJ GENOMIC MEDICINE, 2021.
Genetic Evidence Supporting Fibroblast Growth Factor 21 Signalling as a Pharmacological Target for Cardiometabolic Outcomes and Alzheimer's Disease
Part of Nutrients, 2021.
Genetic liability to insomnia in relation to cardiovascular diseases: a Mendelian randomisation study
Part of European Journal of Epidemiology, p. 393-400, 2021.
Genetic predisposition to allergic diseases is inversely associated with risk of COVID-19
Part of Allergy. European Journal of Allergy and Clinical Immunology, p. 1911-1913, 2021.
Genetically predicted circulating B vitamins in relation to digestive system cancers
Part of British Journal of Cancer, p. 1997-2003, 2021.
Genetically predicted education attainment in relation to somatic and mental health
Part of Scientific Reports, 2021.
Genetically predicted plasma phospholipid arachidonic acid concentrations and 10 site-specific cancers in UK biobank and genetic consortia participants: A mendelian randomization study
Part of Clinical Nutrition, p. 3332-3337, 2021.
Genetically Proxied Inhibition of Coagulation Factors and Risk of Cardiovascular Disease: A Mendelian Randomization Study
Part of Journal of the American Heart Association, 2021.
Genetically proxied interleukin-6 receptor inhibition: opposing associations with COVID-19 and pneumonia
Part of European Respiratory Journal, 2021.
Good general health and lack of family history influence the underestimation of cardiovascular risk: A cross sectional study
Part of European Journal of Cardiovascular Nursing, 2021.
Homocysteine, B vitamins, and cardiovascular disease: a Mendelian randomization study
Part of BMC Medicine, 2021.
Incidence and Outcome of Popliteal Artery Injury Associated with Knee Dislocations, Ligamentous Injuries, and Close to Knee Fractures: A Nationwide Population Based Cohort Study
Part of European Journal of Vascular and Endovascular Surgery, p. 297-304, 2021.
Insulin-like Growth Factor-1, Bone Mineral Density, and Fracture: A Mendelian Randomization Study
Part of Journal of Clinical Endocrinology and Metabolism, p. E1552-E1558, 2021.
Is the Effect of Mediterranean Diet on Hip Fracture Mediated Through Type 2 Diabetes and Body Mass Index?
Part of International Journal of Epidemiology, p. 234-244, 2021.
Lifestyle factors and venous thromboembolism in two cohort studies
Part of Thrombosis Research, p. 119-124, 2021.
Mendelian randomization as a tool for causal inference in human nutrition and metabolism
Part of Current Opinion in Lipidology, p. 1-8, 2021.
Modifiable risk factors for epilepsy: A two-sample Mendelian randomization study
Part of Brain and Behavior, 2021.
Overall and abdominal obesity in relation to venous thromboembolism
Part of Journal of Thrombosis and Haemostasis, p. 460-469, 2021.
Prior loss of body mass index, low body mass index, and central obesity independently contribute to higher rates of fractures in elderly women and men
Part of Journal of Bone and Mineral Research, p. 1288-1299, 2021.
Sleep duration and risk of overall and 22 site-specific cancers: A Mendelian randomization study
Part of International Journal of Cancer, p. 914-920, 2021.
Swedish snuff (snus) and risk of cardiovascular disease and mortality: prospective cohort study of middle-aged and older individuals
Part of BMC Medicine, 2021.
The Nordic Nutrition Recommendations 2022 – prioritisation of topics for de novo systematic reviews
Type 2 diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Elderly Swedish Men and Women: Supplementary material
Type 2 Diabetes and Change in Total Hip Bone Area and Bone Mineral Density in Swedish Men and Women Older Than 55 Years
Part of Journal of Clinical Endocrinology and Metabolism, 2021.
ACE inhibition and cardiometabolic risk factors, lung ACE2 and TMPRSS2 gene expression, and plasma ACE2 levels: a Mendelian randomization study
Part of Royal Society Open Science, 2020.
Alcohol Consumption and Cardiovascular Disease A Mendelian Randomization Study
Part of Circulation, p. 121-127, 2020.
Amount and Intensity of Leisure-Time Physical Activity and Lower Cancer Risk
Part of Journal of Clinical Oncology, p. 686-697, 2020.
An atlas on risk factors for type 2 diabetes: a wide-angled Mendelian randomisation study.
Part of Diabetologia, p. 2359-2371, 2020.
Anti-inflammatory diet and risk of heart failure: two prospective cohort studies
Part of European Journal of Heart Failure, p. 676-682, 2020.
Association of Cardiovascular Risk Factors and Lifestyle Behaviors With Hypertension: A Mendelian Randomization Study
Part of Hypertension, p. 1971-1979, 2020.
Association of genetic variants related to plasma fatty acids with type 2 diabetes mellitus and glycaemic traits: a Mendelian randomisation study
Part of Diabetologia, p. 116-123, 2020.