Bone regeneration and osseointegrated implants

Rehabilitation   

Surgical interventions and the use of biomaterials that result in positive gain for the patient needs to be evaluated both in the clinic and the laboratory. This is done in our project in collaboration with national and international co-workers from the industry and academic sciences. The day-to-day clinical reality is very often about ordinary dental reconstruction and augmentation of bone and surrounding tissues. We connect experimental immunological models with surgical procedures that aim for reconstructing the bone around dental implants and bone replacement therapies in connection with congenital and acquired defects after tumor surgery or trauma.

The project group is working to develop a new generation of guides and patient-specific biomaterials produced with varying techniques that can be more quickly and efficiently integrated into both soft and hard tissues, and with biomechanical properties that meet the load requirements demanded by the situation. One of our major partners is the Mid Sweden University that uses the electron beam melting technique for production of patient specific solutions. Our project includes studies of bone formation and incorporation of the modified implants. The new technologies will be evaluated in extensive preclinical in vivo studies using molecular methods and PET/CT alongside the use of radiology and histology for studying biomaterials to assess how bone reacts, after which they will be tested in actual surgery.

The two slides show the pre-treatment situation (top) with a bone deficient situation not allowing for installation of implants. The bottom picture show bone formation 6 months after a space filled with blood was created in the maxillary sinus cavity. 

The two slides show the pre-treatment situation (top) with a bone deficient situation not allowing for installation of implants. The bottom picture show bone formation 6 months after a space filled with blood was created in the maxillary sinus cavity