Publications in DiVA

Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections

Gronseth, Torstein; Ovchinnikov, Kirill, V; Carlsen, Harald; Benth, Jurate Saltyte et al.

Part of International Wound Journal, p. 120-130, 2023.

DOI for Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections Download full text (pdf) of Lugol's solution and Gentian violet eradicate methicillin-resistant Staphylococcus aureus biofilm in skin wound infections

Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations

Gallus, Roberto; Nauta, Irene H.; Marklund, Linda; Rizzo, Davide et al.

Part of Cancers, 2023.

DOI for Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations Download full text (pdf) of Accuracy of p16 IHC in Classifying HPV-Driven OPSCC in Different Populations

Intrasellar pressure in patients with pituitary adenoma - relation to tumour size and growth pattern

Simander, Gabriel; Eriksson, Per Olof; Lindvall, Peter; Koskinen, Lars-Owe D.

Part of BMC Neurology, 2022.

DOI for Intrasellar pressure in patients with pituitary adenoma - relation to tumour size and growth pattern Download full text (pdf) of Intrasellar pressure in patients with pituitary adenoma - relation to tumour size and growth pattern

Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNA in situ Hybridization and Super-Resolution Structured Illumination Microscopy

Liu, Wei; Rask-Andersen, Helge

Part of Frontiers in Molecular Neuroscience, 2022.

DOI for Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNA in situ Hybridization and Super-Resolution Structured Illumination Microscopy Download full text (pdf) of Na/K-ATPase Gene Expression in the Human Cochlea: A Study Using mRNA in situ Hybridization and Super-Resolution Structured Illumination Microscopy

Internet-based support for informal caregivers to individuals with head and neck cancer (Carer eSupport): a study protocol for the development and feasibility testing of a complex online intervention

Langegård, Ulrica; Cajander, Åsa; Carlsson, Maria E.; von Essen, Louise et al.

Part of BMJ Open, 2022.

DOI for Internet-based support for informal caregivers to individuals with head and neck cancer (Carer eSupport): a study protocol for the development and feasibility testing of a complex online intervention Download full text (pdf) of Internet-based support for informal caregivers to individuals with head and neck cancer (Carer eSupport): a study protocol for the development and feasibility testing of a complex online intervention

CD45RA(+)CD62L(-) ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs

Kokkinou, Efthymia; Pandey, Ram Vinay; Mazzurana, Luca; Gutierrez-Perez, Irene et al.

Part of Science immunology, 2022.

DOI for CD45RA(+)CD62L(-) ILCs in human tissues represent a quiescent local reservoir for the generation of differentiated ILCs

The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea

Rasmussen, Jesper; Lundström, Patrik; Eriksson, Per Olof; Rask-Andersen, Helge et al.

Part of Frontiers in Molecular Neuroscience, 2022.

DOI for The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea Download full text (pdf) of The Acute Effects of Furosemide on Na-K-Cl Cotransporter-1, Fetuin-A and Pigment Epithelium-Derived Factor in the Guinea Pig Cochlea

Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity: The ARTSCAN 2 study

Wennerberg, Johan; Gebre-Medhin, Maria; Nilsson, Per; Brun, Eva et al.

Part of Radiotherapy and Oncology, p. 26-32, 2022.

DOI for Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity: The ARTSCAN 2 study Download full text (pdf) of Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity: The ARTSCAN 2 study

Serum Proteomics in Patients with Head and Neck Cancer: Peripheral Blood Immune Response to Treatment

Astradsson, Thorsteinn; Sellberg, Felix; Ehrsson, Ylva Tiblom; Sandström, Karl et al.

Part of International Journal of Molecular Sciences, 2022.

DOI for Serum Proteomics in Patients with Head and Neck Cancer: Peripheral Blood Immune Response to Treatment Download full text (pdf) of Serum Proteomics in Patients with Head and Neck Cancer: Peripheral Blood Immune Response to Treatment

Self‐reported exercise‐induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents

Veneroni, Chiara; Pompilio, Pasquale Pio; Alving, Kjell; Janson, Christer et al.

Part of Pediatric Allergy and Immunology, 2022.

DOI for Self‐reported exercise‐induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents Download full text (pdf) of Self‐reported exercise‐induced dyspnea and airways obstruction assessed by oscillometry and spirometry in adolescents

Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?

Li, Hao; Staxäng, Karin; Hodik, Monika; Melkersson, Karl-Gunnar et al.

Part of Frontiers in Cell and Developmental Biology, 2022.

DOI for Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing? Download full text (pdf) of Regeneration in the Auditory Organ in Cuban and African Dwarf Crocodiles (Crocodylus rhombifer and Osteolaemus tetraspis) Can We Learn From the Crocodile How to Restore Our Hearing?

Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16

Landin, David; Näsman, Anders; Jara, Sara Jonmarker; Hammarstedt-Nordenvall, Lalle et al.

Part of Viruses, 2022.

DOI for Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16 Download full text (pdf) of Post-Treatment Neck Dissection of Tonsillar and Base of Tongue Squamous Cell Carcinoma in the Era of PET-CT, HPV, and p16

Auditory brainstem implant pitch discrimination and auditory outcome

Hallin, Karin; Rask-Andersen, Helge

Part of ACTA OTO-LARYNGOLOGICA CASE REPORTS, p. 39-43, 2022.

DOI for Auditory brainstem implant pitch discrimination and auditory outcome Download full text (pdf) of Auditory brainstem implant pitch discrimination and auditory outcome

Addressing symptoms that affect patients' eating according to the Head and Neck Patient Symptom Checklist(C)

Granstrom, Brith; Holmlund, Thorbjorn; Laurell, Göran; Fransson, Per et al.

Part of Supportive Care in Cancer, p. 6163-6173, 2022.

DOI for Addressing symptoms that affect patients' eating according to the Head and Neck Patient Symptom Checklist(C) Download full text (pdf) of Addressing symptoms that affect patients' eating according to the Head and Neck Patient Symptom Checklist(C)

Longitudinal Changes in the Fatty Acid Profile in Patients with Head and Neck Cancer: Associations with Treatment and Inflammatory Response

Christou, Constantina; Tiblom Ehrsson, Ylva; Westerbergh, Johan; Risérus, Ulf et al.

Part of Cancers, 2022.

DOI for Longitudinal Changes in the Fatty Acid Profile in Patients with Head and Neck Cancer: Associations with Treatment and Inflammatory Response Download full text (pdf) of Longitudinal Changes in the Fatty Acid Profile in Patients with Head and Neck Cancer: Associations with Treatment and Inflammatory Response

Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register

Hogmo, Anders; Holmberg, Erik; Cange, Hedda Haugen; Reizenstein, Johan et al.

Part of Acta Oncologica, p. 433-440, 2022.

DOI for Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register Download full text (pdf) of Base of tongue squamous cell carcinomas, outcome depending on treatment strategy and p16 status. A population-based study from the Swedish Head and Neck Cancer Register

Visualization of macrophage subsets in the development of the fetal human inner ear

Steinacher, Claudia; Chacko, Lejo Johnson; Liu, Wei; Rask-Andersen, Helge et al.

Part of Frontiers in Immunology, 2022.

DOI for Visualization of macrophage subsets in the development of the fetal human inner ear Download full text (pdf) of Visualization of macrophage subsets in the development of the fetal human inner ear

GJB2 and GJB6 gene transcripts in the human cochlea: A study using RNAscope, confocal, and super-resolution structured illumination microscopy

Liu, Wei; Rask-Andersen, Helge

Part of Frontiers in Molecular Neuroscience, 2022.

DOI for GJB2 and GJB6 gene transcripts in the human cochlea: A study using RNAscope, confocal, and super-resolution structured illumination microscopy Download full text (pdf) of GJB2 and GJB6 gene transcripts in the human cochlea: A study using RNAscope, confocal, and super-resolution structured illumination microscopy

Sjölander, Isabella

Pediatric Obstructive Sleep Apnea: Evaluation of surgical treatments and immunological aspects

2022.

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Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein

Spiegelberg, Diana; Malmberg, Christer; Ehrsson, Ylva Tiblom; Laurell, Göran

Part of Cancers, 2022.

DOI for Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein Download full text (pdf) of Higher Risk of Recurrence in Patients Treated for Head and Neck Cancer with Low BMI and Elevated Levels of C-Reactive Protein

Unlocking the human inner ear for therapeutic intervention

Li, Hao; Agrawal, Sumit; Rohani, Seyed Alireza; Zhu, Ning et al.

Part of Scientific Reports, 2022.

DOI for Unlocking the human inner ear for therapeutic intervention Download full text (pdf) of Unlocking the human inner ear for therapeutic intervention

Mandibular resection in patients with head and neck cancer: acute and long-term complications after reconstruction

Sjostrom, Mats; Danielsson, Daniel; Munck-Wikland, Eva; Nyberg, Jan et al.

Part of Acta Oto-Laryngologica, p. 78-83, 2022.

DOI for Mandibular resection in patients with head and neck cancer: acute and long-term complications after reconstruction Download full text (pdf) of Mandibular resection in patients with head and neck cancer: acute and long-term complications after reconstruction

Designing for Human Well-Being: A Case Study with Informal Caregivers of Individuals with Cancer

Ahmad, Awais; Cajander, Åsa; Johansson, Birgitta; Ehrsson, Ylva Tiblom et al.

Part of Studies in Health Technology and Informatics, p. 214-218, 2022.

DOI for Designing for Human Well-Being: A Case Study with Informal Caregivers of Individuals with Cancer Download full text (pdf) of Designing for Human Well-Being: A Case Study with Informal Caregivers of Individuals with Cancer

Adherence to CPAP therapy in Down syndrome: the population-based DISCOVERY study.

Svensson, Malin; Ekström, Magnus; Sundh, Josefin; Ljunggren, Mirjam et al.

Part of Journal of Clinical Sleep Medicine (JCSM), 2022.

DOI for Adherence to CPAP therapy in Down syndrome: the population-based DISCOVERY study.

Effectiveness of Tonsillectomy vs Modified Uvulopalatopharyngoplasty in Patients With Tonsillar Hypertrophy and Obstructive Sleep Apnea The TEAMUP Randomized Clinical Trial

Sundman, Joar; Nerfeldt, Pia; Fehrm, Johan; Bring, Johan et al.

Part of JAMA Otolaryngology - Head and Neck Surgery, p. 1173-1181, 2022.

DOI for Effectiveness of Tonsillectomy vs Modified Uvulopalatopharyngoplasty in Patients With Tonsillar Hypertrophy and Obstructive Sleep Apnea The TEAMUP Randomized Clinical Trial

Speech in Adults Treated for Unilateral Cleft Lip and Palate as Rated by Naïve Listeners, Speech-Language Pathologists and Patients

Morén, Staffan; Lindestad, Per-åke; Stålhammar, Lilian; Holmström, Mats et al.

Part of Journal of Plastic, Reconstructive & Aesthetic Surgery, 2022.

DOI for Speech in Adults Treated for Unilateral Cleft Lip and Palate as Rated by Naïve Listeners, Speech-Language Pathologists and Patients Download full text (pdf) of Speech in Adults Treated for Unilateral Cleft Lip and Palate as Rated by Naïve Listeners, Speech-Language Pathologists and Patients

Softer, thinner and more complaint cochlear implants with liquid metal

Wang, Bei; Li, Hao; Prasad, Sonal; Xu, Jing et al.

2022.

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Vitamin D in Head and Neck Cancer: a Systematic Review

Makitie, Antti; Tuokkola, Iida; Laurell, Göran; Makitie, Outi et al.

Part of Current Oncology Reports, 2021.

DOI for Vitamin D in Head and Neck Cancer: a Systematic Review Download full text (pdf) of Vitamin D in Head and Neck Cancer: a Systematic Review

HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes

Luque, Maria; Schrott-Fischer, Anneliese; Dudas, Jozsef; Pechriggl, Elisabeth et al.

Part of Journal of Neuroscience Research, p. 699-728, 2021.

DOI for HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes Download full text (pdf) of HCN channels in the mammalian cochlea: Expression pattern, subcellular location, and age-dependent changes

Eight-Year Follow-up of Modified Uvulopalatopharyngoplasty in Patients With Obstructive Sleep Apnea

Sundman, Joar; Browaldh, Nanna; Fehrm, Johan; Friberg, Danielle

Part of The Laryngoscope, p. E307-E313, 2021.

DOI for Eight-Year Follow-up of Modified Uvulopalatopharyngoplasty in Patients With Obstructive Sleep Apnea

Quality of Life in Bell's Palsy: Correlation with Sunnybrook and House-Brackmann Over Time

Bylund, Nina; Hultcrantz, Malou; Jonsson, Lars; Marsk, Elin

Part of The Laryngoscope, p. E612-E618, 2021.

DOI for Quality of Life in Bell's Palsy: Correlation with Sunnybrook and House-Brackmann Over Time Download full text (pdf) of Quality of Life in Bell's Palsy: Correlation with Sunnybrook and House-Brackmann Over Time

Mapping Health-Related Quality of Life, Anxiety, and Depression in Patients with Head and Neck Cancer Diagnosed with Malnutrition Defined by GLIM

Ehrsson, Ylva Tiblom; Fransson, Per; Einarsson, Sandra

Part of Nutrients, 2021.

DOI for Mapping Health-Related Quality of Life, Anxiety, and Depression in Patients with Head and Neck Cancer Diagnosed with Malnutrition Defined by GLIM Download full text (pdf) of Mapping Health-Related Quality of Life, Anxiety, and Depression in Patients with Head and Neck Cancer Diagnosed with Malnutrition Defined by GLIM

Vestibular Organ and Cochlear Implantation-A Synchrotron and Micro-CT Study

Li, Hao; Schart-Moren, Nadine; Rajan, Gunesh; Shaw, Jeremy et al.

Part of Frontiers in Neurology, 2021.

DOI for Vestibular Organ and Cochlear Implantation-A Synchrotron and Micro-CT Study Download full text (pdf) of Vestibular Organ and Cochlear Implantation-A Synchrotron and Micro-CT Study

High Prevalence of Exercise-induced Laryngeal Obstruction in a Cohort of Elite Cross-country Skiers

Irewall, Tommie; Bäcklund, Catharina; Nordang, Leif; Ryding, Marie et al.

Part of Medicine & Science in Sports & Exercise, p. 1134-1141, 2021.

DOI for High Prevalence of Exercise-induced Laryngeal Obstruction in a Cohort of Elite Cross-country Skiers Download full text (pdf) of High Prevalence of Exercise-induced Laryngeal Obstruction in a Cohort of Elite Cross-country Skiers

Svindlande vindlingar: En personlig berättelse om örats inre skönhet

Rask-Andersen, Helge

Acta Universitatis Upsaliensis, 2021.

A Nordic survey of the management of palliative care in patients with head and neck cancer

Boëthius, Helena; Saarto, Tiina; Laurell, Göran; Farnebo, Lovisa et al.

Part of European Archives of Oto-Rhino-Laryngology, p. 2027-2032, 2021.

DOI for A Nordic survey of the management of palliative care in patients with head and neck cancer Download full text (pdf) of A Nordic survey of the management of palliative care in patients with head and neck cancer

A Synchrotron and Micro-CT Study of the Human Endolymphatic Duct System: Is Meniere's Disease Caused by an Acute Endolymph Backflow?

Li, Hao; Rajan, Gunesh P.; Shaw, Jeremy; Rohani, Seyed Alireza et al.

Part of Frontiers in Surgery, 2021.

DOI for A Synchrotron and Micro-CT Study of the Human Endolymphatic Duct System: Is Meniere's Disease Caused by an Acute Endolymph Backflow? Download full text (pdf) of A Synchrotron and Micro-CT Study of the Human Endolymphatic Duct System: Is Meniere's Disease Caused by an Acute Endolymph Backflow?

Aeration of the Human Prussak's Space: A 3D Synchrotron Imaging Study

Li, Hao; Giese, Dina; Rohani, Seyed Alireza; Zhu, Ning et al.

Part of Otology and Neurotology, p. E894-E904, 2021.

DOI for Aeration of the Human Prussak's Space: A 3D Synchrotron Imaging Study

Three-Dimensional Modeling and Measurement of the Human Cochlear Hook Region: Considerations for Tonotopic Mapping

Helpard, Luke; Li, Hao; Rohani, Seyed A.; Rask-Andersen, Helge et al.

Part of Otology and Neurotology, p. E658-E665, 2021.

DOI for Three-Dimensional Modeling and Measurement of the Human Cochlear Hook Region: Considerations for Tonotopic Mapping

Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

Axelsson, Lars; Holmberg, Erik; Nyman, Jan; Högmo, Anders et al.

Part of International Archives of Otorhinolaryngology, p. E433-E442, 2021.

DOI for Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival Download full text (pdf) of Swedish National Multicenter Study on Head and Neck Cancer of Unknown Primary: Prognostic Factors and Impact of Treatment on Survival

Newborn Hearing Screening and Intervention in Children with Unilateral Hearing Impairment: Clinical Practices in Three Nordic Countries

Jakhelln Laugen, Nina; Erixon, Elsa; Huttunen, Kerttu; Mäki-Torkko, Elina et al.

Part of Journal of Clinical Medicine, 2021.

DOI for Newborn Hearing Screening and Intervention in Children with Unilateral Hearing Impairment: Clinical Practices in Three Nordic Countries

Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

Pirttilä, Kristian; Laurell, Göran; Pettersson, Curt; Hedeland, Mikael

Part of Metabolites, 2021.

DOI for Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics Download full text (pdf) of Automated Sequential Analysis of Hydrophilic and Lipophilic Fractions of Biological Samples: Increasing Single-Injection Chemical Coverage in Untargeted Metabolomics

An Approach for Individualized Cochlear Frequency Mapping Determined From 3D Synchrotron Radiation Phase-Contrast Imaging

Helpard, Luke; Li, Hao; Rohani, Seyed A.; Zhu, Ning et al.

Part of IEEE Transactions on Biomedical Engineering, p. 3602-3611, 2021.

DOI for An Approach for Individualized Cochlear Frequency Mapping Determined From 3D Synchrotron Radiation Phase-Contrast Imaging Download full text (pdf) of An Approach for Individualized Cochlear Frequency Mapping Determined From 3D Synchrotron Radiation Phase-Contrast Imaging

Distribution of Immune Cells Including Macrophages in the Human Cochlea

Liu, Wei; Danckwardt-Lillieström, Niklas; Schrott-Fischer, Anneliese; Glueckert, Rudolf et al.

Part of Frontiers in Neurology, 2021.

DOI for Distribution of Immune Cells Including Macrophages in the Human Cochlea Download full text (pdf) of Distribution of Immune Cells Including Macrophages in the Human Cochlea

A national study of health-related quality of life in patients with cancer of the base of the tongue compared to the general population and to patients with tonsillar carcinoma

Berg, Malin; Adnan, Ali; Hogmo, Anders; Sjodin, Helena et al.

Part of Head and Neck, p. 3843-3856, 2021.

DOI for A national study of health-related quality of life in patients with cancer of the base of the tongue compared to the general population and to patients with tonsillar carcinoma

Identification of resident memory CD8⁺ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

Niessl, Julia; Sekine, Takuya; Lange, Joshua; Konya, Viktoria et al.

Part of Science immunology, 2021.

DOI for Identification of resident memory CD8⁺ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue Download full text (pdf) of Identification of resident memory CD8⁺ T cells with functional specificity for SARS-CoV-2 in unexposed oropharyngeal lymphoid tissue

A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens

Liu, Wei; Johansson, Åsa; Rask-Andersen, Helge; Rask-Andersen, Mathias

Part of BMC Medicine, 2021.

DOI for A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens Download full text (pdf) of A combined genome-wide association and molecular study of age-related hearing loss in H. sapiens

Nasal symptoms increase the risk of snoring and snoring increases the risk of nasal symptoms. A longitudinal population study.

Värendh, Maria; Janson, Christer; Bengtsson, Caroline; Hellgren, Johan et al.

Part of Sleep and Breathing, p. 1851-1857, 2021.

DOI for Nasal symptoms increase the risk of snoring and snoring increases the risk of nasal symptoms. A longitudinal population study. Download full text (pdf) of Nasal symptoms increase the risk of snoring and snoring increases the risk of nasal symptoms. A longitudinal population study.

Circulating fatty acids in patients with head and neck cancer after treatment: an explorative study with a one-year perspective

Christou, Constantina; Ehrsson, Ylva Tiblom; Lampa, Erik; Risérus, Ulf et al.

Part of Acta Oto-Laryngologica, p. 878-884, 2021.

DOI for Circulating fatty acids in patients with head and neck cancer after treatment: an explorative study with a one-year perspective Download full text (pdf) of Circulating fatty acids in patients with head and neck cancer after treatment: an explorative study with a one-year perspective

Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging

Li, Hao; Helpard, Luke; Ekeroot, Jonas; Rohani, Seyed Alireza et al.

Part of Scientific Reports, 2021.

DOI for Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging Download full text (pdf) of Three-dimensional tonotopic mapping of the human cochlea based on synchrotron radiation phase-contrast imaging