Endocrine Surgery

The Endocrine Surgical Research An x-ray pictureGroup runs studies of genetics, diagnosis and treatment of endocrine tumours, in order to identify genes involved in tumour development and progression, and to ultimately provide possibilities for new treatment. In clinical studies genetic changes are related to the disease course of individual tumours, with the overall aim to improve diagnosis and treatment in patients with endocrine tumour disease. 

Genetics and treatment of endocrine tumors 

Endocrine tumours are of special interest in tumour biology because of a common extended disease course, and often presence of only few specific genetic changes, which can be related to variable tumour biology. For many endocrine tumours histopathology can often not distinguish tumours with more malignant biological features, and there is a general hope that genetic differences will provide better means of discrimination. Genetic studies are expected to become of great importance for the clinical management by predicting prognosis, and genetic defects may be used as targets for new treatment. The overall aim of the studies is to identify tumour genes and other prognostic markers of importance for the development and progression of endocrine tumours, reveal gene changes with new technology, and investigate new possibilities of treatment against tumour progression. 

Biobank 

As an overall resource we have access to >3000 specimens and blood samples from patients operated for endocrine tumours during >20 years. The samples, stored at Uppsala Biobank, have being used in many previous studies and is a valuable and important source in our studies. 

Adrenal

Adrenomedullary tumors - Pheochromocytoma 

Studies of pheochromocytoma and paraganglioma have used the latest DNA sequencing techniques in order to characterize polymorphisms, mutations, deletions and insertions in DNA, from both benign and malignant tumours. Epigenetic derangements have been studied, and the research is performed in close collaboration with the group of Experimental Surgery.

A picture od mesentieric artery and vein, and duodenum

Adrenocortical tumours 

In a study performed in collaborations with Yale University, and which was published in Science, the breakthrough of genetic knowledge of adrenal tumours was initiated. A mutation in KCNJ5, an ion channel, was noted in approximately 45% of tumours. Further, we have revealed mutations in CACNA1D in a subset of these tumours as well, and in the cortisol-producing tumours in PRKACA. We are currently looking at differencies between benign and malignant adrenal tumours, also on the epigenetic level.

Parathyroid 

Our parathyroid studies are currently focused on identifying differences between parathyroid adenoma and carcinoma. We have noted that derangements in the structure or function of beta cathenin, HIC1, APC, EZH2 may be important, as well as differences in methylation or hydromethylation in the parathyroid tissue.

Small intestinal Neuroendocrine tumours (SI-NET; formerly midgut carcinoids)

SI-NETs have been studied with several different methods in order to identify molecular derangements to understand the underlying mechanisms for tumour development. Initially, we identified the presence of a suspect tumour suppressor gene for SI-NETs on chromosome 18q. Further studies have utilized expression microarrays, sequencing and methylation arrays to reveal characteristics for more or less aggressive tumours. We have identified bad prognostic signs in presence of peritoneal carcinosis and are currently investigating the Clinical studies have established a cohort of >600 individuals with SI-NET, in which we have characterized novel prognostic factors, especially peritoneal carcinomatosis. This is further analyzed by performing SNP and expression arrays and CNV analyses for determining the genetic signature. A nested case-control study of 900 individuals has passed the data collecting phase and is now in the analysis phase.

Pancreatic NETs 

Several previous studies have investigated gene changes associated with pancreatic NETs. In a recent study we could after exome sequencing identify mutations in YY1 in approximately 40% of insulinomas. Further work includes characterization of DAXX mutations and expression. Further analyses of genetic derangements in multiple endocrine neoplasia type 1 (MEN1) is also performed. 

Clinical studies 

Clinical studies of primary hyperparathyroidism (HPT) focus on relations between calcium and/or parathyroid hormone (PTH) and aldosterone, and increased mortality in cardiovascular disease, utilizing epidemiological methods but also the PIVUS cohort, a well characterized cohort which has been followed for 10 years and thoroughly scrutinized regarding vascular changes, atherosclerosis and cardiovascular morbidity. The calcium metabolic situation in obese individuals as well as after gastric by-pass is also studied using Cica-clamp and intervention with vitamin D treatment among several methods.

Graves' disease

This disease is studied regarding the calcium metabolic regulation, highlighting skeletal derangements, unknown autoimmune antibodies and genetic predisposition by SNP arrays.


Members of the group 2016

Senior investigators
Gunnar Westin, Professor, Molecular genetics and epigenetics of endocrine tumours
Per Hellman, Professor, Endocrine surgery
Peter Stålberg, Ass Professor, Endocrine surgery
Olov Norlén, MD, PhD

Clinicians
Ola Hessman, MD, PhD - attending surgeon
Hella Hultin, MD, PhD - attending surgeon

Technicians
Birgitta Bondeson

PhD students
John Eriksson (Prognosis of SI-NETs)
Elham Barazeghi (Parathyroid research)
Rajani Maharjan (Adrenal tumours)
Johan Kugelberg (Adrenal Tumours)
Kosmas Daskalakis (SI-NET)

Dissertations (last 5 years)
Maria Annerbo
Tobias Åkerström
Katarina Edfeldt
Joakim Crona
Alberto Delgado Verdugo
Hella Hultin
Jessica Svedlund
Olov Norlén
Johanna Sandgren
Niklas Zar
Joakim Hennings
Tijana Krajisnik


Publications
The last years publikations are depicted in the Institutions Research Report Annual report. Earlier and later articles can be searched in the database for publikations DiVA (Digitala Vetenskapliga Arkivet – Digital scientific archive).

Collaboration

Collaboration is continuously running with other groups within Academic Hospital: Uppsala Centre of Excellence for Endocrine Tumors.

Collaboration also continuous with Yale University (Endocrine Neoplasia Laboratory, Dept of Surgery, responsible Ass Professor T Carling – with previous dissertation within our research group, and Professor Richard Lifton) for studie of tumor genetics with new methods. P Björklund has established “Experim.ental Endocrine Surgery” which we collaborate with closely.

Collaboration also continuous with other international groups:
Professor H Dralle, Halle, Germany, Martin Walz, Essen, Germany, Ass Professor Kenko Cupisti, Dusseldorf, Tyskland

Publikationer i DiVA 2018-2019, endokrinkirurgi

  • Johansson, Mattias; Carreras-Torres, Robert; Scelo, Ghislaine; Purdue, Mark P. et al.

    The influence of obesity-related factors in the etiology of renal cell carcinoma—A mendelian randomization study

    Part of PLoS Medicine, 2019.

    Open access
  • Karakatsanis, Andreas; Hersi, Abdi-Fatah; Pistiolis, L.; Bagge, R. Olofsson et al.

    Effect of preoperative injection of superparamagnetic iron oxide particles on rates of sentinel lymph node dissection in women undergoing surgery for ductal carcinoma in situ (SentiNot study)

    Part of British Journal of Surgery, p. 720-728, 2019.

  • Plym, Anna; Johansson, Anna L., V; Bower, Hannah; Voss, Margaretha et al.

    Causes of sick leave, disability pension, and death following a breast cancer diagnosis in women of working age

    Part of Breast, p. 48-55, 2019.

  • Wennstig, Anna-Karin; Garmo, Hans; Isacsson, Ulf; Gagliardi, Giovanna et al.

    The relationship between radiation doses to coronary arteries and location of coronary stenosis requiring intervention in breast cancer survivors

    Part of Radiation Oncology, 2019.

    Open access
  • Arthur, Rhonda; Møller, Henrik; Garmo, Hans; Häggström, Christel et al.

    Serum glucose, triglycerides, and cholesterol in relation to prostate cancer death in the Swedish AMORIS study

    Part of Cancer Causes and Control, p. 195-206, 2019.

  • Hersi, Abdi-Fatah; Eriksson, Staffan; Ramos, Joakim; Abdsaleh, Shahin et al.

    A combined, totally magnetic technique with a magnetic marker for non-palpable tumour localization and superparamagnetic iron oxide nanoparticles for sentinel lymph node detection in breast cancer surgery

    Part of European Journal of Surgical Oncology, p. 544-549, 2019.

  • Bill-Axelson, Anna; Holmberg, Lars; Garmo, Hans

    Radical Surgery or Watchful Waiting in Prostate Cancer Reply

    Part of New England Journal of Medicine, p. 1084-1084, 2019.

  • Cazzaniga, Walter; Garmo, Hans; Robinson, David; Holmberg, Lars et al.

    Mortality after radical prostatectomy in a matched contemporary cohort in Sweden compared to the Scandinavian Prostate Cancer Group 4 (SPCG-4) study

    Part of BJU International, p. 421-428, 2019.

  • Wärnberg, Fredrik; Stigberg, Evelina; Obondo, Christine; Olofsson, Helena et al.

    Long-Term Outcome After Retro-Areolar Versus Peri-Tumoral Injection of Superparamagnetic Iron Oxide Nanoparticles (SPIO) for Sentinel Lymph Node Detection in Breast Cancer Surgery.

    Part of Annals of Surgical Oncology, p. 1247-1253, 2019.

    Open access
  • Linder, Fredrik; Holmberg, Lina; Björck, Martin; Juhlin, Claes et al.

    A prospective stepped wedge cohort evaluation of the new national trauma team activation criteria in Sweden - the TRAUMALERT study.

    Part of Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019.

    Open access
  • Essen, Anneli; Santaolalla, Aida; Garmo, Hans; Hammar, Niklas et al.

    Baseline serum folate, vitamin B12 and the risk of prostate and breast cancer using data from the Swedish AMORIS cohort

    Part of Cancer Causes and Control, p. 603-615, 2019.

    Open access
  • Myte, Robin; Gylling, Bjorn; Haggstrom, Jenny; Häggström, Christel et al.

    Metabolic factors and the risk of colorectal cancer by KRAS and BRAF mutation status

    Part of International Journal of Cancer, p. 327-337, 2019.

  • Daskalakis, Kosmas; Chatzelis, Eleftherios; Tsoli, Marina; Papadopoulou-Marketou, Nektaria et al.

    Endocrine paraneoplastic syndromes in patients with neuroendocrine neoplasms

    Part of Endocrine (Basingstoke), p. 384-392, 2019.

    Open access
  • Häggström, Christel; Garmo, Hans; de Luna, Xavier; Van Hemelrijck, Mieke et al.

    Survival after radiotherapy versus radical cystectomy for primary muscle-invasive bladder cancer: A Swedish nationwide population-based cohort study

    Part of Cancer Medicine, p. 2196-2204, 2019.

    Open access
  • Daskalakis, Kosmas; Tsoli, Marina; Srirajaskanthan, Raj; Chatzellis, Eleftherios et al.

    Lung Metastases in Patients with Well-Differentiated Gastroenteropancreatic Neuroendocrine Neoplasms: An Appraisal of the Validity of Thoracic Imaging Surveillance

    Part of Neuroendocrinology, p. 308-316, 2019.

  • Beckmann, Kerri; Russell, Beth; Josephs, Debra; Garmo, Hans et al.

    Chronic inflammatory diseases, anti-inflammatory medications and risk of prostate cancer: a population-based case-control study

    Part of BMC Cancer, 2019.

    Open access
  • Bessa, Agustina; Maclennan, Steven; Enting, Deborah; Bryan, Richard et al.

    Consensus in Bladder Cancer Research Priorities Between Patients and Healthcare Professionals Using a Four-stage Modified Delphi Method

    Part of European Urology, p. 258-259, 2019.

  • Daskalakis, Kosmas; Tsoli, Marina; Angelousi, Anna; Kassi, Evanthia et al.

    Anti-tumour activity of everolimus and sunitinib in neuroendocrine neoplasms

    Part of Endocrine Connections, p. 641-653, 2019.

    Open access
  • Vyakaranam, Achyut Ram; Crona, Joakim; Norlén, Olov; Hellman, Per et al.

    C-11-hydroxy-ephedrine-PET/CT in the Diagnosis of Pheochromocytoma and Paraganglioma

    Part of Cancers, 2019.

    Open access
  • Åkerström, Göran; Stålberg, Peter; Skogseid, Britt

    Multiple Endocrine Neoplasia type 2

    Part of Textbook of Complex General Surgical Oncology, 2018.

  • Watson, Sarah; Chandler, Rebecca E.; Taavola, Henric; Harmark, Linda et al.

    Safety Concerns Reported by Patients Identified in a Collaborative Signal Detection Workshop using VigiBase: Results and Reflections from Lareb and Uppsala Monitoring Centre

    Part of Drug Safety, p. 203-212, 2018.

    Open access
  • Daskalakis, Kosmas; Karakatsanis, Andreas; Hessman, Ola; Stuart, Heather C. et al.

    Association of a Prophylactic surgical approach to Stage IV Small Intestinal Neuroendocrine Tumors with Survival.

    Part of JAMA Oncology, p. 183-189, 2018.

  • Plate, Susann; Emilsson, Louise; Söderberg, Martin; Brandberg, Yvonne et al.

    High experienced continuity in breast cancer care is associated with high health related quality of life

    Part of BMC Health Services Research, 2018.

    Open access
  • Bosco, Cecilia; Garmo, Hans; Hammar, Niklas; Walldius, Göran et al.

    Glucose, lipids and gamma-glutamyl transferase measured before prostate cancer diagnosis and secondly diagnosed primary tumours: a prospective study in the Swedish AMORIS cohort

    Part of BMC Cancer, 2018.

    Open access
  • Crawley, Danielle; Chamberlain, Florence; Garmo, Hans; Rudman, Sarah et al.

    A systematic review of the literature exploring the interplay between prostate cancer and type two diabetes mellitus

    Part of ecancermedicalscience, 2018.

    Open access
  • Wärnberg, Madeleine; Karakatsanis, Andreas; Abdsaleh, Shahin; Wärnberg, Fredrik

    Abstract P3-01-11: Discoloration after injection of super paramagnetic iron oxide (SPIO) for sentinel node biopsy. A long term qualitative follow-up study

    Part of Cancer Research, 2018.

  • Charalampoudis, Petros; Karakatsanis, Andreas

    Neoadjuvant chemotherapy for early breast cancer

    Part of The Lancet Oncology, p. E128-E128, 2018.

  • Tomic, Katarina; Ventimiglia, Eugenio; Robinson, David; Häggström, Christel et al.

    Socioeconomic status and diagnosis, treatment, and mortality in men with prostate cancer. Nationwide population-based study

    Part of International Journal of Cancer, p. 2478-2484, 2018.

  • Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

    Ex Vivo Activity of Cytotoxic Drugs and Targeted Agents in Small Intestinal Neuroendocrine Tumors

    Part of Neuroendocrinology, p. 189-189, 2018.

  • Daskalakis, Kosmas; Norlén, Olov; Karakatsanis, Andreas; Hellman, Per et al.

    Ex vivo activity of cytotoxic drugs and targeted agents in small intestinal neuroendocrine tumors

    Part of Endocrine-Related Cancer, p. 471-480, 2018.

  • Karakatsanis, Andreas; Tasoulis, M. K.; Wärnberg, Fredrik; Nilsson, Greger et al.

    Meta-analysis of neoadjuvant therapy and its impact in facilitating breast conservation in operable breast cancer

    Part of British Journal of Surgery, p. 469-481, 2018.

  • Fraser, Sheila; Norlén, Olov; Bender, Kyle; Davidson, Joanne et al.

    Randomized trial of low versus high carbon dioxide insufflation pressures in posterior retroperitoneoscopic adrenalectomy

    Part of Surgery, p. 1128-1133, 2018.

  • Wennstig, A. K.; Garmo, H.; Isacsson, Ulf; Gagliardi, G. et al.

    The relationship between radiation doses to coronary arteries and later intervention requiring coronary stenosis in breast cancer

    Part of European Journal of Cancer, p. S61-S62, 2018.

  • Obondo, C.; Karakatsanis, Andreas; Eriksson, S.; Hersi, A. F. et al.

    SentiDose - A dose optimizing study with SiennaXP, a superparamagnetic iron oxide for sentinel node detection

    Part of European Journal of Cancer, p. S79-S79, 2018.

  • Wadsten, C.; Wärnberg, Fredrik; Tolockiene, E.; Hartman, J. et al.

    Biomarkers in DCIS associated with breast cancer death

    Part of European Journal of Cancer, p. S67-S68, 2018.

  • Van Hemelrijck, Mieke; Ulmer, Hanno; Nagel, Gabriele; Peter, Raphael Simon et al.

    Longitudinal study of body mass index, dyslipidemia, hyperglycemia, and hypertension in 60,000 men and women in Sweden and Austria

    Part of PLoS ONE, 2018.

    Open access
  • Wärnberg, Fredrik; Garmo, Hans; Folkvaljon, Yasin; Holmberg, Lars et al.

    Abstract GS5-08: A validation of DCIS biological risk profile in a randomised study for radiation therapy with 20 year follow-up (SweDCIS)

    Part of Cancer Research, 2018.

  • Sjöström, Martin; Staaf, Johan; Eden, Patrik; Wärnberg, Fredrik et al.

    Identification and validation of single-sample breast cancer radiosensitivity gene expression predictors

    Part of Breast Cancer Research, 2018.

    Open access
  • Salem, F. A.; Almquist, M.; Nordenström, E.; Dahlberg, J. et al.

    A Nested Case-Control Study on the Risk of Surgical Site Infection After Thyroid Surgery

    Part of World Journal of Surgery, p. 2454-2461, 2018.

    Open access
  • Wadsten, C.; Wennstig, A.-K.; Garmo, H.; Nilsson, Greger et al.

    Risk of ischemic heart disease after radiotherapy for ductal carcinoma in situ

    Part of Breast Cancer Research and Treatment, p. 95-101, 2018.

    Open access
  • Rosénsalen, Akademiska Sjukhuset, Uppsala 2018-05-18 09:00

    Eriksson, John

    Prognostic Factors for Death in Small Intestinal Neuroendocrine Tumours

    Open access
  • Enell, Jacob; Bayadsi, Haytham; Lundgren, Ewa; Hennings, Joakim

    Primary Hyperparathyroidism is Underdiagnosed and Suboptimally Treated in the Clinical Setting

    Part of World Journal of Surgery, p. 2825-2834, 2018.

    Open access
  • Häggström, Christel; Van Hemelrijck, Mieke; Garmo, Hans; Robinson, David et al.

    Heterogeneity in risk of prostate cancer: A Swedish population-based cohort study of competing risks and Type 2 diabetes mellitus

    Part of International Journal of Cancer, p. 1868-1875, 2018.

    Open access
  • Eriksson, Louise; Bergh, Jonas; Humphreys, Keith; Wärnberg, Fredrik et al.

    Time from breast cancer diagnosis to therapeutic surgery and breast cancer prognosis: A population-based cohort study

    Part of International Journal of Cancer, p. 1093-1104, 2018.

  • Norlén, Olov; Montan, Harald; Hellman, Per; Stålberg, Peter et al.

    Preoperative Ga-68-DOTA-Somatostatin Analog-PET/CT Hybrid Imaging Increases Detection Rate of Intra-abdominal Small Intestinal Neuroendocrine Tumor Lesions

    Part of World Journal of Surgery, p. 498-505, 2018.

  • Vrielink, O. M.; Engelsman, A. F.; Hemmer, P. H. J.; de Vries, J. et al.

    Multicentre study evaluating the surgical learning curve for posterior retroperitoneoscopic adrenalectomy

    Part of British Journal of Surgery, p. 544-551, 2018.

  • Maharjan, Rajani; Backman, Samuel; Åkerström, Tobias; Hellman, Per et al.

    Comprehensive analysis of CTNNB1 in adrenocortical carcinomas: Identification of novel mutations and correlation to survival

    Part of Scientific Reports, 2018.

    Open access
  • Garske, Ulrike; Sandström, Mattias; Fröss-Baron, Katarzyna; Lundin, Lars et al.

    Prospective observational study of 177Lu-DOTA-octreotate therapy in 200 patients with advanced metastasized neuroendocrine tumours (NETs): feasibility and impact of a dosimetry-guided study protocol on outcome and toxicity

    Part of European Journal of Nuclear Medicine and Molecular Imaging, p. 970-988, 2018.

    Open access
  • Grönberg, Malin; Nilsson, Cecilia; Markholm, Ida; Hedenfalk, Ingrid et al.

    Ghrelin expression is associated with a favorable outcome in male breast cancer

    Part of Scientific Reports, 2018.

    Open access
  • Crawley, Danielle; Garmo, Hans; Rudman, Sarah; Stattin, Pär et al.

    Association between type 2 diabetes, curative treatment and survival in men with intermediate- and high-risk localized prostate cancer.

    Part of BJU International, p. 209-216, 2018.

  • Arthur, R.; Williams, R.; Garmo, Hans; Holmberg, Lars et al.

    Serum inflammatory markers in relation to prostate cancer severity and death in the Swedish AMORIS study

    Part of International Journal of Cancer, p. 2254-2262, 2018.

  • Bosco, Cecilia; Wong, Chloe; Garmo, Hans; Crawley, Danielle et al.

    Drugs for metabolic conditions and prostate cancer death in men on GnRH agonists.

    Part of BJU International, p. 260-267, 2018.

  • Daskalakis, Kosmas; Tsolakis, Apostolos V.

    Upfront surgery of small intestinal neuroendocrine tumors. Time to reconsider?

    Part of World Journal of Gastroenterology, p. 3201-3203, 2018.

    Open access
  • Karakatsanis, Andreas; Obondo, Christine; Abdsaleh, Shahin; Hersi, Abdi-Fatah et al.

    Optimisation of breast MRI compatibility after sentinel node biopsy with paramagnetic tracers

    Part of European Journal of Surgical Oncology, p. 731-732, 2018.

  • Sartori, Daniele; Grundmark, Birgitta

    Letter to the Editor Regarding "Natalizumab-Associated Primary Central Nervous System Lymphoma"

    Part of World Neurosurgery, p. 473-474, 2018.

  • Svee, Andreas; Mani, Maria; Sandquist, K.; Audolfsson, T. et al.

    Survival and risk of breast cancer recurrence after breast reconstruction with deep inferior epigastric perforator flap

    Part of British Journal of Surgery, p. 1446-1453, 2018.

  • Hultin, Hella; Stevens, Katharina; Sundbom, Magnus

    Cholecalciferol Injections Are Effective in Hypovitaminosis D After Duodenal Switch: a Randomized Controlled Study

    Part of Obesity Surgery, p. 3007-3011, 2018.

    Open access
  • Boer, Jeltje; Ederveen, Ellen; Grundmark, Birgitta

    Desloratadine and depression, a drug safety signal based on worldwide spontaneous reporting of side effects

    Part of Upsala Journal of Medical Sciences, p. 174-178, 2018.

    Open access
  • Söderbäck, Harald; Gunnarsson, Ulf; Hellman, Per; Sandblom, Gabriel

    Incisional hernia after surgery for colorectal cancer: a population-based register study

    Part of International Journal of Colorectal Disease, p. 1411-1417, 2018.

    Open access
  • Sartori, D.; Grundmark, Birgitta; Ellenius, J.

    Cognitive Patterns in Pharmacovigilance Assessments

    Part of Drug Safety, p. 1169-1170, 2018.

  • Birgegård, Gunnar; Folkvaljon, Folke; Garmo, Hans; Holmberg, Lars et al.

    Leukemic transformation and second cancers in 3649 patients with high-risk essential thrombocythemia in the EXELS study

    Part of Leukemia research, p. 105-109, 2018.

  • Teleka, Stanley; Häggström, Christel; Nagel, Gabriele; Bjorge, Tone et al.

    Risk of bladder cancer by disease severity in relation to metabolic factors and smoking: A prospective pooled cohort study of 800,000 men and women

    Part of International Journal of Cancer, p. 3071-3082, 2018.

  • Eriksson, John; Garmo, J E H; Ihre-Lundgren, C; Hellman, Per

    Prognostic factors for death after surgery for small intestinal neuroendocrine tumours.

    Part of BJS open, p. 345 345-352 352, 2018.

    Open access
  • Crona, Joakim; Backman, Samuel; Welin, Staffan; Taieb, David et al.

    RNA-Sequencing Analysis of Adrenocortical Carcinoma, Pheochromocytoma and Paraganglioma from a Pan-Cancer Perspective

    Part of Cancers, 2018.

    Open access
  • Andersson, Roland; Hellman, Per; Johansson, Jan; Lagergren, Jesper et al.

    Selektiv nivåstrukturering av svensk kirurgi behövs.

    Part of Läkartidningen, 2018.

  • Daskalakis, Kosmas; Kaltsas, Gregory; Öberg, Kjell; Tsolakis, Apostolos V.

    Lung Carcinoids: Long-Term Surgical Results and the Lack of Prognostic Value of Somatostatin Receptors and Other Novel Immunohistochemical Markers

    Part of Neuroendocrinology, p. 355-365, 2018.

  • Åström, Lennart; Sandin, Fredrik; Holmberg, Lars

    Good Prognosis following a PSA Bounce after High Dose Rate Brachytherapy and External Radiotherapy in Prostate Cancer

    Part of Radiotherapy and Oncology, p. 561-566, 2018.

  • Bill-Axelson, Anna; Holmberg, Lars; Garmo, Hans; Taari, Kimmo et al.

    Radical Prostatectomy or Watchful Waiting in Prostate Cancer: 29-Year Follow-up

    Part of New England Journal of Medicine, p. 2319-2329, 2018.

  • Wickberg, Asa; Magnuson, Anders; Holmberg, Lars; Adami, Hans-Olov et al.

    Influence of the subtype on local recurrence risk of breast cancer with or without radiation therapy

    Part of Breast, p. 54-60, 2018.

  • Li, Weiqiang; Middha, Mridu; Bicak, Mesude; Sjoberg, Daniel D. et al.

    Genome-wide Scan Identifies Role for AOX1 in Prostate Cancer Survival

    Part of European Urology, p. 710-719, 2018.

  • Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

    U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

    Part of Acta Oncologica, p. 187-194, 2018.

    Open access
  • Bremer, Troy; Whitworth, Pat W.; Patel, Rakesh; Savala, Jess et al.

    A Biological Signature for Breast Ductal Carcinoma In Situ to Predict Radiotherapy Benefit and Assess Recurrence Risk

    Part of Clinical Cancer Research, p. 5895-5901, 2018.

  • Karakatsanis, Andreas; Olofsson, Helena; Stålberg, Peter; Bergkvist, Leif et al.

    Simplifying Logistics and Avoiding the Unnecessary in Patients with Breast Cancer Undergoing Sentinel Node Biopsy. A Prospective Feasibility Trial of the Preoperative Injection of Super Paramagnetic Iron Oxide Nanoparticles

    Part of Scandinavian Journal of Surgery, p. 130-137, 2018.

  • Johansson, Eva; Steineck, Gunnar; Holmberg, Lars; Johansson, Jan-Erik et al.

    Quality of Life after Radical Prostatectomy or Watchful Waiting With or Without Androgen Deprivation Therapy: The SPCG-4 Randomized Trial

    Part of European Association of Urology, p. 134 134-142 142, 2018.

  • Barazeghi, Elham; Prabhawa, Surendra; Norlén, Olov; Hellman, Per et al.

    Decrease of 5-hydroxymethylcytosine and TET1 with nuclear exclusion of TET2 in small intestinal neuroendocrine tumors.

    Part of BMC Cancer, 2018.

    Open access
  • Krauss, Tobias; Ferrara, Alfonso Massimiliano; Links, Thera P.; Wellner, Ulrich et al.

    Preventive medicine of von Hippel-Lindau disease-associated pancreatic neuroendocrine tumors

    Part of Endocrine-Related Cancer, p. 783-793, 2018.

  • Pettersson, A; Robinson, D; Garmo, H; Holmberg, Lars et al.

    Age at diagnosis and prostate cancer treatment and prognosis: a population-based cohort study

    Part of Annals of Oncology, p. 377-385, 2018.

  • Bergengren, Oskar; Garmo, Hans; Bratt, Ola; Holmberg, Lars et al.

    Satisfaction with Care Among Men with Localised Prostate Cancer: A Nationwide Population-based Study

    Part of European Urology Oncology, p. 37 37-45 45, 2018.

  • Sun, Yibao; Xu, Zhaoyang; Strell, Carina; Moro, Carlos Fernandez et al.

    Detection of Breast Tumour Tissue Regions in Histopathological Images using Convolutional Neural Networks

    Part of 2018 IEEE International Conference on Image Processing, Applications and Systems (IPAS), p. 98-103, 2018.