Transplantation Surgery

Kidney transplantations have been done in Uppsala since 1969
Kidney transplantations have been
done in Uppsala since 1969. 
Photo: Bengt von Zur-Mühlen

Transplantation research is based on clinical need but encompasses both clinical and experimental research.

Most of the research is done in a collaborative fashion within the University in particular with the department of Clinical Immunology, but also Pathology, Nephrology, Anaesthesiology, Neurosurgery and Radiology are involved.

The field of transplantation research is very heterogeneous but it has a common focus of clinical need.

Although the topics can be listed as separate items these may in several aspects be interrelated either by technology or goal. Under the broad heading transplantation immunology we conduct clinical research on tolerance and the generation of regulatory T-cells to reduce/abolish the use of immunsuppression. Also research is directed to overcome the AB0-barrier as well as anti-HLA antibody barriers. The latter is dependent on the use of complement inactivation and/or IgG-degradation.

The second topic may be assembled under the broad heading of regenerative medicine. The common denominator is the knowledge that organs transplanted are damaged all the way through the procedure until after re-perfusion. The following damaging events have been identified: brain death, harvesting procedure, storage with ischemia and finally re-perfusion injuries. It is also recognised that all these factors together generate rather non-specific damages, which may switch the organs from a neutral to a pro-inflammatory state. Further, it is recognised that especially the storage period with cold storage or machine perfusion, warm or cold, may offer an opportunity of repair by endothelial or perfusion solution modulation to improve the long-term transplant outcome.

More specifically ischemia re-perfusion is studied in a large animal model in renal, pancreatic and islet transplants. Furthermore studies are in progress to explore the possibilities of blockade of apoptosis.

Outside of the heading of regenerative medicine patient management and live donor management are important areas for both technical and psychological development. Thus, we have research/developmental programmes for clinical islet transplantation, live donor kidney donation, clinical pancreastransplantation and management of malignancies after transplantation.

Members of the research group:
Bengt von Zur-Mühlen, Principal investigator, Ass Professor
Tomas Lorant, Ass professor
Olle Korsgren, Professor
Jan Eriksson, Professor
Per-Ola Carlsson, Professor
Amir Sedigh, MD PhD
Vivan Hellström, MD PhD
Shinji Yamamoto, MD PhD
Tim Scholz, MD, PhD
Pål Foyn Jörgensen, MD, PhD

Publications 2018-2019, Transplantation Surgery

  • Sedigh, Amir; Nordling, Sofia; Carlsson, Fredrik; Larsson, Erik et al.

    Perfusion of Porcine Kidneys With Macromolecular Heparin Reduces Early Ischemia Reperfusion Injury

    Part of Transplantation, p. 420-427, 2019.

  • Wadström, Jonas; von Zur-Mühlen, Bengt; Lennerling, Annette; Westman, Kerstin et al.

    Living Anonymous Renal Donors Do Not Regret: Intermediate and Long-Term Follow-Up with a Focus on Motives and Psychosocial Outcomes

    Part of Annals of Transplantation, p. 234-241, 2019.

  • Tedesco-Silva, Helio; Pascual, Julio; Viklicky, Ondrej; Basic-Jukic, Nikolina et al.

    Safety of Everolimus With Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplants: An Analysis From the Randomized TRANSFORM Study

    Part of Transplantation, p. 1953-1963, 2019.

  • von Zur-Mühlen, Bengt; Lundgren, Torbjorn; Bayman, Levent; Berne, Christian et al.

    Open Randomized Multicenter Study to Evaluate Safety and Efficacy of Low Molecular Weight Sulfated Dextran in Islet Transplantation

    Part of Transplantation, p. 630-637, 2019.

    Open access
  • Berstad, Audun E.; Brabrand, Knut; Horneland, Rune; Syversveen, Trygve et al.

    Microbubble contrast-enhanced ultrasound in the vascular evaluation after pancreas transplantation: a single-center experience

    Part of Acta Radiologica, p. 1224-1231, 2019.

  • Glotz, Denis; Russ, Graeme; Rostaing, Lionel; Legendre, Christophe et al.

    Safety and efficacy of eculizumab for the prevention of antibody-mediated rejection after deceased-donor kidney transplantation in patients with preformed donor-specific antibodies

    Part of American Journal of Transplantation, p. 2865-2875, 2019.

    Open access
  • Nordling, Sofia; Brännström, Johan; Carlsson, Fredrik; Lu, Bo et al.

    Enhanced protection of the renal vascular endothelium improves early outcome in kidney transplantation: Preclinical investigations in pig and mouse

    Part of Scientific Reports, 2018.

    Open access
  • Wadström, J.; von Zur-Mühlen, Bengt; Yamamoto, Shinji

    Few Gender Differences in Attitudes and Experiences after Live Kidney Donation, with Minor Changes over Time

    Part of American Journal of Transplantation, p. 451-451, 2018.

  • Järnum, S.; Runström, A.; Winstedt, L.; Lorant, Tomas et al.

    Effects of IdeS on HLA-SAB, C1q-SAB and CDC-XM

    Part of American Journal of Transplantation, p. 370-371, 2018.

  • Foss, Stein; Nordheim, Espen; Sorensen, Dag W.; Syversen, Torgunn B. et al.

    First Scandinavian Protocol for Controlled Donation After Circulatory Death Using Normothermic Regional Perfusion

    Part of Transplantation direct, 2018.

    Open access
  • Eich, Torsten; Ståhle, Magnus U.; Gustafsson, Bengt; Horneland, Rune et al.

    Calcium: A Crucial Potentiator for Efficient Enzyme Digestion of the Human Pancreas

    Part of Cell Transplantation, p. 1031-1038, 2018.

    Open access
  • Wadström, Jonas; von Zur-Mühlen, Bengt; Yamamoto, Shinji

    Few Gender Differences in Attitudes and Experiences after Live Kidney Donation, with Minor Changes over Time

    Part of Transplantation, p. S336-S336, 2018.

  • von Zur-Mühlen, Bengt; Wintzell, Viktor; Levine, Aaron; Rosenlund, Mats et al.

    Healthcare Resource Use, Cost, and Sick Leave Following Kidney Transplantation in Sweden: A Population-Based, 5-Year, Retrospective Study of Outcomes: COIN

    Part of Annals of Transplantation, p. 852-866, 2018.

    Open access
  • Lorant, Tomas; Bengtsson, Mats; Eich, Torsten; Eriksson, Britt-Marie et al.

    Safety, immunogenicity, pharmacokinetics, and efficacy of degradation of anti-HLA antibodies by IdeS (imlifidase) in chronic kidney disease patients.

    Part of American Journal of Transplantation, p. 2752-2762, 2018.

    Open access
  • Carlsson, Per-Ola; Espes, Daniel; Sedigh, Amir; Rotem, Avi et al.

    Transplantation of macroencapsulated human islets within the bioartificial pancreas βAir to patients with type 1 diabetes mellitus

    Part of American Journal of Transplantation, p. 1735-1744, 2018.

    Open access