Upper abdominal surgery

Surgeons during an operationThe research in Upper abdominal surgery is focused on four main areas; esophageal and gastric cancer, bariatric surgery, hepatic surgery, and biliary- and pancreatic surgery.

Esophageal and Gastric Cancer

Principal investigator: Magnus Sundbom

In the field of esophageal- and gastric cancer, we study the use of PET-MRI for loco-regional evaluation of esophageal cancer and the use of micro dialysis to identify early ischemia in the gastric tube. We participate in an international multicenter study on early complications. Patient outcome is studied on a national level in collaboration with the national quality register, NREV.

Duodenal switch
Duodenal switch

Bariatric Surgery

Principal investigator: Magnus Sundbom

In bariatric surgery, we have three main areas of research; surgical technique, postoperative changes in gastrointestinal physiology and long term results. Our research is clinical and based on operated patients with the aim to improve surgical technique and understand the altered physiology. We perform Duodenal Switch (DS) in patients with super obesity, i.e. BMI>50 kg/m2, and laparoscopic gastric bypass (GBP) and gastric sleeve (GS) routinely.

At present, we are conducting a national study on treatment of early complications, changes in gastrointestinal function, calcium and vitamin-D, as well as long term results after duodenal switch and gastric bypass in patients with BMI>50. We are also performing a 10-year follow-up of all our GBP-operated patients, demonstrating good weight result in satisfied patients. The general effects of bariatric surgery on gastrointestinal function is studied in several PhD projects, using blood sampling and validated questionnaires.

Much of our work is performed in collaboration with other units in the hospital or at the University, such as the Dept of Endocrinology, the Metabolic unit at the University Hospital, and the Institution of Radiology, Oncology, and Radiation Sciences.

Members of the research group Esophageal/Gastric cancer and Bariatric surgery 2018

Magnus Sundbom, Professor
Jakob Hedberg, Ass professor
David Edholm, MD, PhD
Eduardo Sima, MD, PhD
Gustav Linder, MD, PhD
Zakaria Bekhali, MD
Martin Skogar, MD
Khalid Elias, MD
Bjarni Vidarsson, MD
Eladio Cabrera, MD
Katarina Stevens, MD

Hepatic Surgery

Principal investigator: Ulf Haglund

In hepatic surgery we have focused on defining the possible risk following liver resection induced by pre-operative chemotherapy. We have studied the clinical outcome in the patient material from our institution of approximately 500 resected patients with liver metastasis from colo-rectal cancer during the last 12 years. More than half of the patients receive pre-operative chemotherapy and some patients develop sinusoidal obstructions syndrome. In a project using pre-operative 3T MR we have studied patients with and with-out pre-operative chemotherapy the day before surgery with special techniques to reveal and grade steatosis, steatohepatitis and portal flow. The results are related to the histopathological evaluation and to the clinical outcome. Two of the studies are recently published and further MR studies are planned. In collaboration with prof. Per Artursson, department of pharmacy, we have studies aimed at developing a model using cultured human liver cells, obtained from waste liver tissue after resection for tumours. The cultured cells will be used to study membrane transport function, the influence of preoperative chemotherapy as well as the influence of cytostatic drugs on this function. A safety and effect study on irreversible electroporation (IRE) for liver tumours (as a complement to liver surgery, maximum 2 with a diameter of 3 cm) are running.

Members of the research group
Ulf Haglund, MD, PhD, Professor Emeritus
Agneta Norén, MD, PhD
Frans Duraj, MD
Jozef Urdzik, MD
 

Biliary-Pancreatic Surgery

Principal investigator: Britt-Marie Karlson

The biliary-pancreatic group has focused on surgery for gall stones, perioperative cholangiography.and quality of life. Long term results after endoscopic sphincterotomy, particularly in patients with gall stone-related pancreatitis, are under evaluation. A novel project on irreversible electroporation (IRE) in patients with inoperable pancreatic cancer has started. In collaboration with Department of Medical Sciences, studies in primary sclerosing cholangitis are ongoing and a consecutive patient material with this disease is accumulated with endoscopic cholangiographic data.

Members of the research group
Britt-Marie Karlson, MD, PhD
Stefan Linder, Associate Professor, MD, PhD
Ann Langerth, MD
Christopher Månsson, MD
 

Publications 2018-2019, Upper Abdominal Surgery

  • Hedstrandsalen, Ingång 70 bv, Akademiska sjukhuset, Uppsala 2019-01-12 09:00

    Månsson, Christopher

    Irreversible electroporation of pancreatic adenocarcinoma

    Open access
  • Claassen, Y. H. M.; Bastiaannet, E.; Hartgrink, H. H.; Dikken, J. L. et al.

    International comparison of treatment strategy and survival in metastatic gastric cancer

    Part of BJS OPEN, p. 56 56-61 61, 2019.

    Open access
  • Tingstedt, Bobby; Andersson, Bodil; Jonsson, Claes; Formichov, Victoria et al.

    First results from the Swedish National Pancreatic and Periampullary Cancer Registry

    Part of HPB, p. 34-42, 2019.

  • Linder, Stefan; Linder, Gustav; Månsson, Christopher

    Treatment of de Garengeot's hernia: a meta-analysis

    Part of Hernia, p. 131-141, 2019.

    Open access
  • Ölander, Magnus; Wiśniewski, Jacek R.; Flörkemeier, Inken; Handin, Niklas et al.

    A simple approach for restoration of differentiation and function in cryopreserved human hepatocytes

    Part of Archives of Toxicology, p. 819-829, 2019.

    Open access
  • Pouwels, Sjaak; Topal, Besir; Knook, Mireille T.; Celik, Alper et al.

    Interaction of obesity and atrial fibrillation: an overview of pathophysiology and clinical management

    Part of Expert Review of Cardiovascular Therapy, p. 209-223, 2019.

  • Hasselgren, Kristina; Sandstrom, Per; Røsok, Bård Ingvald; Sparrelid, Ernesto et al.

    Future Liver Remnant (FLR) Increase in Patients with Colorectal Liver Metastases Is Highest the First Week After Portal Vein Occlusion: FLR Increase in Patients with CRLM Is Highest the First Week After PVO

    Part of Journal of Gastrointestinal Surgery, p. 556-562, 2019.

    Open access
  • Linder, Fredrik; Holmberg, Lina; Björck, Martin; Juhlin, Claes et al.

    A prospective stepped wedge cohort evaluation of the new national trauma team activation criteria in Sweden - the TRAUMALERT study.

    Part of Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2019.

    Open access
  • Sandström, Per; Rosok, Bard I.; Sparrelid, Ernesto; Larsen, Peter Norgaard et al.

    Response to "ALPPS Versus Conventional Two-stage Hepatectomy in Patients With Advanced Colorectal Liver Metastases"

    Part of Annals of Surgery, p. E16-E17, 2019.

  • Sandström, Per; Røsok, Bård I.; Sparrelid, Ernesto; Lindell, Gert et al.

    Response to the Comment on "Should We Have a Little More Patience With the Conventional 2-Stage Hepatectomy?''

    Part of Annals of Surgery, p. E33-E34, 2019.

  • Grönwallsalen, Ingång 70, BV, Akademiska sjukhuset, Uppsala 2019-05-17 13:00

    Löfling Skogar, Martin

    Bariatric Surgery: Outcomes after Gastric Bypass and Duodenal Switch

    Open access
  • Tsimogiannis, Konstantinos; Karlbom, Urban; Lundin, Erik; Graf, Wilhelm

    Long-term outcome after segmental colonic resection for slow transit constipation

    Part of International Journal of Colorectal Disease, p. 1013-1019, 2019.

    Open access
  • Nilsen, Inger; Sundbom, Magnus; Abrahamsson, Niclas; Hänni, Arvo

    Comparison of Meal Pattern and Postprandial Glucose Response in Duodenal Switch and Gastric Bypass Patients

    Part of Obesity Surgery, p. 2210-2216, 2019.

    Open access
  • Månsson, Christopher; Brahmstaedt, Richard; Nygren, Peter; Nilsson, Anders et al.

    Percutaneous Irreversible Electroporation as First Line Treatment of Locally Advanced Pancreatic Cancer

    Part of Anticancer Research, p. 2509-2512, 2019.

  • Sköldberg, Filip; Granlund, J.; Discacciati, A.; Hjern, F. et al.

    Incidence and lifetime risk of hospitalization and surgery for diverticular disease

    Part of British Journal of Surgery, p. 930-939, 2019.

  • Stenberg, Erik; Persson, Carina; Näslund, Erik; Ottosson, Johan et al.

    The impact of socioeconomic factors on the early postoperative complication rate after laparoscopic gastric bypass surgery: A register-based cohort study

    Part of Surgery for Obesity and Related Diseases, p. 575-581, 2019.

  • Moren, Åsa; Sundbom, Magnus; Ottosson, Johan; Granstam, Elisabet

    Response: Debate continues. Gastric bypass surgery does not increase the risk for sight-threatening diabetic retinopathy

    Part of Acta Ophthalmologica, p. E807-E808, 2019.

  • Almby, Kristina E.; Abrahamsson, Niclas; Lundqvist, Martin H.; Hammar, Ulf et al.

    Effects of GLP-1 on counter-regulatory responses during hypoglycemia after GBP surgery

    Part of European Journal of Endocrinology, p. 161-171, 2019.

  • Katsogiannos, Petros; Kamble, Prasad G.; Boersma, Greta J.; Karlsson, F. Anders et al.

    Early Changes in Adipose Tissue Morphology, Gene Expression, and Metabolism After RYGB in Patients With Obesity and T2D

    Part of Journal of Clinical Endocrinology and Metabolism, p. 2601-2613, 2019.

  • Syrén, Eva-Lena; Eriksson, Staffan; Enochsson, L.; Eklund, Arne et al.

    Risk factors for pancreatitis following endoscopic retrograde cholangiopancreatography

    Part of BJS OPEN, p. 485 485-489 489, 2019.

    Open access
  • Linder, Gustav; Korsavidou Hult, Nafsika; Bjerner, Tomas; Ahlström, Håkan et al.

    F-18-FDG-PET/MRI in preoperative staging of oesophageal and gastroesophageal junctional cancer

    Part of Clinical Radiology, p. 718-725, 2019.

  • Halim, Abdul; Degerblad, Marie; Sundbom, Magnus; Karlbom, Urban et al.

    Glucagon-like peptide-1 inhibits prandial gastrointestinal motility through myenteric neuronal mechanisms in humans

    Part of Journal of Clinical Endocrinology and Metabolism, p. 575-585, 2018.

  • Linder, Gustav; Sandin, Fredrik; Johansson, Jan; Lindblad, Mats et al.

    Patient education-level affects treatment allocation and prognosis in esophageal- and gastroesophageal junctional cancer in Sweden.

    Part of Cancer Epidemiology, p. 91-98, 2018.

  • Dubbelboer, Ilse R; Lilienberg, Elsa; Karalli, Amar; Axelsson, Rimma et al.

    Reply to "Comment on 'In Vivo Drug Delivery Performance of Lipiodol-Based Emulsion or Drug-Eluting Beads in Patients with Hepatocellular Carcinoma'"

    Part of Molecular Pharmaceutics, p. 336-340, 2018.

  • Grönwallsalen, ingång 70bv, Akademiska sjukhuset, Uppsala 2018-05-11 09:00

    Linder, Gustav

    Esophageal- and Gastroesophageal Junctional Cancer: Aspects on Staging, Treatment and Results

    Open access
  • Valdimarsson, Valentinus T.; Syk, Ingvar; Lindell, Gert; Norén, Agneta et al.

    Outcomes of liver-first strategy and classical strategy for synchronous colorectal liver metastases in Sweden

    Part of HPB, p. 441-447, 2018.

  • Sellberg, Fanny; Possmark, Sofie; Ghaderi, Ata; Näslund, Erik et al.

    A dissonance-based intervention for women post roux-en-Y gastric bypass surgery aiming at improving quality of life and physical activity 24 months after surgery: study protocol for a randomized controlled trial

    Part of BMC Surgery, 2018.

    Open access
  • Morén, Åsa; Sundbom, Magnus; Ottosson, Johan; Granstam, Elisabet

    Gastric bypass surgery does not increase the risk for sight-threatening diabetic retinopathy

    Part of Acta Ophthalmologica, p. 279-282, 2018.

  • Birgisson, H; Tsimogiannis, Kostas; Freyhult, Eva; Kamali-Moghaddam, Masood

    Plasma Protein Profiling Reveal Osteoprotegerin as a Marker of Prognostic Impact for Colorectal Cancer

    Part of Translational Oncology, p. 1034-1043, 2018.

    Open access
  • Jarbrink-Sehgal, M. Ellionore; Schmidt, Peter T.; Sköldberg, Filip; Hemmingsson, Tomas et al.

    Lifestyle Factors in Late Adolescence Associate With Later Development of Diverticular Disease Requiring Hospitalization

    Part of Clinical Gastroenterology and Hepatology, p. 1474-+, 2018.

  • Visser, Els; Edholm, David; Smithers, B. Mark; Thomson, Iain G. et al.

    Neoadjuvant chemotherapy or chemoradiotherapy for adenocarcinoma of the esophagus

    Part of Journal of Surgical Oncology, p. 1687-1696, 2018.

  • Hultin, Hella; Stevens, Katharina; Sundbom, Magnus

    Cholecalciferol Injections Are Effective in Hypovitaminosis D After Duodenal Switch: a Randomized Controlled Study

    Part of Obesity Surgery, p. 3007-3011, 2018.

    Open access
  • Vidarsson, Bjarni; Sundbom, Magnus; Edholm, David

    LEAK AT GASTROJEJUNOSTOMY AFTER ROUX-EN-Y GASTRIC BYPASS-40,844 PATIENTS FROM THE SCANDINAVIAN OBESITY SURGERY REGISTRY (SOREG)

    Part of Obesity Surgery, p. 215-215, 2018.

  • Poelemeijer, Y.; Liem, R.; Vage, V.; Mala, T. et al.

    PERIOPERATIVE OUTCOMES OF PRIMARY BARIATRIC SURGERY IN NORTH-WESTERN EUROPE: A POOLED MULTINATIONAL REGISTRY ANALYSIS

    Part of Obesity Surgery, p. 92-92, 2018.

  • Edholm, David

    Early intake of solid food after Roux-en-Y gastric bypass and complications. A cohort study from the Scandinavian Obesity Surgery Registry

    Part of Surgery for Obesity and Related Diseases, p. 1256-1260, 2018.

  • Poelemeijer, Youri Q. M.; Liem, Ronald S. L.; Våge, Villy; Mala, Tom et al.

    Perioperative Outcomes of Primary Bariatric Surgery in North-Western Europe: a Pooled Multinational Registry Analysis

    Part of Obesity Surgery, p. 3916-3922, 2018.

    Open access
  • Elias, Khalid; Bekhali, Zakaria; Hedberg, Jakob; Graf, Wilhelm et al.

    Changes in bowel habits and patient-scored symptoms after Roux-en-Y gastric bypass and biliopancreatic diversion with duodenal switch

    Part of Surgery for Obesity and Related Diseases, p. 144-149, 2018.

  • Gilg, Stefan; Sandström, Per; Rizell, Magnus; Lindell, Gert et al.

    The impact of post-hepatectomy liver failure on mortality: a population-based study

    Part of Scandinavian Journal of Gastroenterology, p. 1335-1339, 2018.

    Open access
  • Norén, Agneta; Sandstrom, P.; Gunnarsdottir, K.; Ardnor, B. et al.

    Identification of Inequalities in the Selection of Liver Surgery for Colorectal Liver Metastases in Sweden

    Part of Scandinavian Journal of Surgery, p. 294-301, 2018.

  • Gilg, Stefan; Sparrelid, Ernesto; Saraste, Lars; Nowak, Greg et al.

    The Molecular Adsorbent Recirculating System in Posthepatectomy Liver Failure: Results From a Prospective Phase I Study

    Part of HEPATOLOGY COMMUNICATIONS, p. 445 445-454 454, 2018.

    Open access
  • Bushati, M.; Rovers, K. P.; Sommariva, A.; Sugarbaker, P. H. et al.

    The current practice of cytoreductive surgery and HIPEC for colorectal peritoneal metastases: Results of a worldwide web-based survey of the Peritoneal Surface Oncology Group International (PSOGI)

    Part of European Journal of Surgical Oncology, p. 1942-1948, 2018.

  • Sandström, Per; Rosok, Bard I.; Sparrelid, Ernesto; Lindell, Gert et al.

    Response "Unresectable Colorectal Liver Metastases: When Definitions Matter to Appropriately Assess Extreme Liver Resection Techniques''

    Part of Annals of Surgery, p. E83-E85, 2018.

  • Moberger, Peter; Sköldberg, Filip; Birgisson, Helgi

    Evaluation of the Swedish Colorectal Cancer Registry: an overview of completeness, timeliness, comparability and validity

    Part of Acta Oncologica, p. 1611-1621, 2018.

    Open access
  • Vårdskolans Aula, Västmanlands Hospital, entrance 21, Västerås 2019-02-08 09:00

    Isacson, Daniel

    Treatment of Acute Uncomplicated Colonic Diverticulitis

    Open access
  • Tepelenis, Kostas; Tsimogiannis, Konstantinos; Zikos, Nikolaos; Koulas, Spyridon et al.

    Laparoscopic versus open approach to neurolytic celiac plexus block in inoperable pancreatic cancer

    Part of ANZ journal of surgery, p. E767-E771, 2018.

  • Glimelius, Bengt; Melin, Beatrice; Enblad, Gunilla; Alafuzoff, Irina et al.

    U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.

    Part of Acta Oncologica, p. 187-194, 2018.

    Open access
  • Weiss, Frederik; Hammer, Helen S.; Klein, Kathrin; Planatscher, Hannes et al.

    Direct Quantification of Cytochromes P450 and Drug Transporters-A Rapid, Targeted Mass Spectrometry-Based Immunoassay Panel for Tissues and Cell Culture Lysates

    Part of Drug Metabolism And Disposition, p. 387-396, 2018.

    Open access