Cardiothoracic anesthesia and intensive care, clinical and experimental research

At the section of cardiothoracic anesthesia and intensive care, clinical and experimental research is performed in collaboration mainly with the section of cardiothoracic surgery and the department of anesthesiology and intensive care. Several cardiothoracic anesthesiologists and one perfusionist are involved in projects of high clinical relevance, for instance cerebral perfusion during cardiopulmonary bypass, cerebral perfusion during aortic arch surgery, coagulation/hemostasis, the physiology of one-lung ventilation and the effects of hyperglycemia.

Experimental selective antegrade cerebral perfusion (SACP)

  • Aortic arch surgery requires circulatory arrest and cerebral protection relies on deep hypothermia, selective perfusion of the brain by antegrade (SACP) or retrograde routes or combinations thereof. Perioperative morbidity and mortality is substantial. 

One-lung ventilation with capnothorax 

  • Airway separation with unilateral lung closure (one-lung ventilation, OLV) is used to facilitate exposure during lung surgery and thoracoscopic surgery.

Venous congestion and cerebral perfusion in cardiopulmonary bypass 

  • Venous congestion is a threat to perfusion during cardiopulmonary bypass (CPB), and occasionally venous drainage cannot be adequately ensured in the clinical setting.

Hyperglycemia and cerebral ischemia 

  • Hyperglycemia is associated with increased complication rate after cardiac surgery and tight glycemic control is established in the postoperative stage.

Hemostasis and cardiac surgery

  • The progression of aortic stenosis involves both blood coagulation and fibrinolysis.
    • Aortic arch surgery requires circulatory arrest and cerebral protection relies on deep hypothermia, selective perfusion of the brain by antegrade (SACP) or retrograde routes or combinations thereof. Perioperative morbidity and mortality is substantial. 

Contact

Fredrik Lennmyr, Associate Professor

Postgraduates

Ulrica Alström, MD, PhD, Consultant Anesthesiologist
Ove Jansson, MD, PhD, Consultant Anesthesiologist
Thomas Tovedal, PhD, Perfusionist

Last modified: 2021-05-03