The aim of our project is to generate new knowledge regarding the pathophysiology of
post-operative pain and facilitate developments of new efficient and safe postoperative pain relief. More specifically we perform a randomized, placebo-controlled, double-blind clinical drug trail (phase IV) of s-ketamin using wisdom tooth extraction as a pain model. The aim is to evaluate the effects and the tolerability of preoperative infusion of s-ketamin in subanesthetic doses. By comparing the patients reported experience with biomedical markers of inflammation in plasma and saliva we hope to find ways to improve our understanding of the pathophysiology of postoperative pain. To our knowledge, these aspects have never been studied in oral surgery patients or in acute pain. This study is to be regarded as hypothesis generating, given the new methodology involved. The study is a collaboration with Lars Sand, professor at Oslo University and Åke Tegelberg, professor at Örebro/Malmö University.